Healthcare

Amorphous Solid Dispersion (ASD)

Solubility enhancement of poorly soluble APIs.

Amorphous solid dispersion is a technology for solubility enhancement of drugs. Solubility of a large number of APIs is limited by their crystalline nature which results in poor solubility. If the absorption in the GI tract is acceptable, these compounds are classified as BCD class II. By dispersing the drug on a molecular level in a polymeric carrier, an amorphous state of the API is maintained in the drug product overcoming solubility issues. Shin-Etsu AQOAT® HPMCAS is the leading excipient in solubility enhancement by amorphous solid dispersion technology. Also PHARMACOAT® and HPMCP show good results in solubility enhancement.

Filter applications by:

    Solvent free methods (HME)

    Hot melt extrusion is an example of a solvent free process for the preparation of amorphous solid dispersion. The polymer is blended with the API and fed into an hot melt extruder. The carrier polymer is melting and the API dissolves in the polymer during the process. Kneading elements in the extruder add additional shear and energy to the system to create a homogenous extrudate. The extrudate is pelletized or milled and filled into capsules or compressed into tablets. Another option is to extrude filaments for 3D-printing and the tablet is printed.

    Recommended products

    GradesDescriptionPharmacopoeiaOriginRecommendationKnowledge Base
    PHARMACOAT® 603 Hypromellose 2910, 3 mPasUSP, EP, JPJapan Very suitable Select
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    Dissolution behavior of various HPMC lower viscosity grades [P-014]
    Effect of moisture content on the mechanical properties of cast HPMC films [P-005]
    Effect of plasticizers and other additives on the mechanical properties of cast HPMC films [P-008]
    Film properties of HPMC and MC [G-002]
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    PHARMACOAT® 645 Hypromellose 2910, 4.5 mPasUSP, EP, JPJapan Very suitable Select
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    Application of L-HPC and PHARMACOAT® in twin screw granulation for continuous manufacturing [L-039]
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    Coating formulation for logo tablets [P-013]
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    Dissolution behavior of various HPMC lower viscosity grades [P-014]
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    Dissolution behavior of various HPMC lower viscosity grades [P-014]
    Effect of moisture content on the mechanical properties of cast HPMC films [P-005]
    Effect of plasticizers and other additives on the mechanical properties of cast HPMC films [P-008]
    Film properties of HPMC and MC [G-002]
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    Solubility of PHARMACOAT® 606 in acetone/water mixtures [P-016]
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    Enteric coating of soft gelatin capsules with HPMCP [H-018]
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    HPMCP - typical coating conditions for tablets (1) [H-002]
    HPMCP - typical coating conditions for tablets (2) [H-003]
    HPMCP - typical coating conditions for tablets [H-001]
    Hydrolysis of HPMCP in ethanol-water solution [H-005]
    IR spectrums of HPMCP and Shin-Etsu AQOAT® [H-017, A-054]
    Itraconazole 65 mg capsule using HPMPC-50 by solid dispersion approach [H-021]
    Residual solvent in ethanol/water HPMPC-55 tablet coating [H-007]
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    Aqueous based enteric formulation of Shin-Etsu AQOAT® (HPMCAS) containing amino acid as a stabilizer [A-049]
    Aqueous dispersion coating using Shin-Etsu AQOAT® (HPMCAS) (Coating parameters of a tablet batch size 5-100kg) [A-002]
    Aqueous dispersion coating using Shin-Etsu AQOAT® (HPMCAS) (Preparation of coating dispersion) [A-001]
    Aqueous dispersion coating using Shin-Etsu AQOAT® (HPMCAS) (Using a small tabletop coating machine we coated tablet batch size of 300g) [A-006]
    Aqueous enteric coating for lansoprazole using Shin-Etsu AQOAT® (HPMCAS) [A-059]
    Aqueous enteric coating for soft gelatin capsule using Shin-Etsu AQOAT® (HPMCAS) [A-043]
    Aqueous enteric coating for soft gelatin capsule with Shin-Etsu AQOAT® (HPMCAS) [A-062]
    Aqueous enteric coating using Shin-Etsu AQOAT® (HPMCAS) for Mini-Tablets [A-053]
    Aqueous enteric coating with Shin-Etsu AQOAT® (HPMCAS): ammonia-neutralized method - part 1: solution and film properties [A-008]
    Aqueous enteric coating with Shin-Etsu AQOAT® (HPMCAS): ammonia-neutralized method - part 2: examples of coating applications [A-012]
    Aqueous enteric coating with Shin-Etsu AQOAT® (HPMCAS): ammonia-neutralized method - part 3: stability of the coated preparations [A-013]
    Aqueous fine particle coating with angled spray [A-044]
    Aqueous formulation of Shin-Etsu AQOAT® (HPMCAS) containing an amino acid as stabilizer - comparison of formulation and process parameters on different coating equipment [A-055]
    Comparative study of various coating methods with Shin-Etsu AQOAT® (HPMCAS) for pellets [A-060]
    Comparison of mini-tablets enteric coating with Shin-Etsu AQOAT® (HPMCAS) using perforated pan or fluid bed coating equipment [A-056]
    Concentration - viscosity curve of Shin-Etsu AQOAT® (HPMCAS) [A-064]
    Direct compression of spray dried dispersion [A-072]
    Dissolution behavior of coated fine particles by aqueous and solvent coating [A-045, H-013]
    Effect of hot melt extrusion on the physicochemical properties of Shin-Etsu AQOAT® (HPMCAS) [A-017]
    Effect of substitution of Shin-Etsu AQOAT® (HPMCAS) on dissolution profile of nifedipine solid dispersions (SD) prepared by Hot Melt Extrusion [A-032]
    Enteric coating of hard gelatin capsules using Shin-Etsu AQOAT® (HPMCAS) [A-029]
    Enteric coating of omeprazol granules using Shin-Etsu AQOAT® (HPMCAS) [A-031]
    Enteric coating with Shin-Etsu AQOAT® (HPMCAS) by using water-ethanol solution [A-004]
    Examples of aqueous dispersion coating using Shin-Etsu AQOAT® (HPMCAS) [A-003]
    Impact of process parameters to solid dispersion particles [A-071]
    Influence of alcohol on gastric resistance of Shin-Etsu AQOAT® (HPMCAS) [A-014]
    IR spectrums of HPMCP and Shin-Etsu AQOAT® [H-017, A-054]
    Mechanical properties of hot melt extruded amorphous solid dispersion with Shin-Etsu AQOAT® (HPMCAS) [A-073]
    Milling and downstream processing of hot melt extruded (HME) amorphous solid dispersion with Shin-Etsu AQOAT® (HPMCAS) [A-067]
    Minimum film formation temperature of Shin-Etsu AQOAT® (HPMCAS) (2) [A-047]
    Minimum film formation temperature of Shin-Etsu AQOAT® (HPMCAS) [A-005]
    Molecular weight of Shin-Etsu AQOAT® (HPMCAS) [A-007]
    Nifedipine solid dispersion using Shin-Etsu AQOAT® - preparation by HME and downstream processing [A-051]
    Partially neutralized coating technique using Shin-Etsu AQOAT® (HPMCAS) [A-037]
    Scale-up of tablet enteric coating using the partially ammonia neutralized Shin-Etsu AQOAT® (HPMCAS) dispersion [A-068]
    Solid dispersions (SD) using Shin-Etsu AQOAT® (HPMCAS) by holt melt extrusion [A-018]
    Solubility of Shin-Etsu AQOAT® (HPMCAS) in alkali solutions for cleaning media after coating operations [A-021]
    Solubility of Shin-Etsu AQOAT® (HPMCAS) in mixed organic solvents [A-035]
    Solution preparation of HPMCP and Shin-Etsu AQOAT® (HPMCAS) [H-019, A-058]
    Stability of Shin-Etsu AQOAT® (HPMCAS) at high temperatures [A-010]
    Taste masking coating for quinine tablets [A-061]
    Taste masking coating using Shin-Etsu AQOAT® (HPMCAS) and PHARMACOAT® with controlled release [A-063, P-018]
    Triacetin as an alternative plasticizer for aqueous dispersion with Shin-Etsu AQOAT® (HPMCAS) [A-057]
    Shin-Etsu AQOAT® AS-MMP HPMCAS, 200 µm, opening pH>6.0NF, JPJapan Very suitable Select
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    3D printing tablets with Shin-Etsu AQOAT® (HPMCAS) [A-069]
    Application of Shin-Etsu AQOAT® (HPMCAS) as a carrier in solid dispersion [A-028]
    Application of Shin-Etsu AQOAT® (HPMCAS) in extended release (ER) matrix tablet formulation [A-070]
    Aqueous based enteric formulation of Shin-Etsu AQOAT® (HPMCAS) containing amino acid as a stabilizer [A-049]
    Aqueous dispersion coating using Shin-Etsu AQOAT® (HPMCAS) (Coating parameters of a tablet batch size 5-100kg) [A-002]
    Aqueous dispersion coating using Shin-Etsu AQOAT® (HPMCAS) (Preparation of coating dispersion) [A-001]
    Aqueous dispersion coating using Shin-Etsu AQOAT® (HPMCAS) (Using a small tabletop coating machine we coated tablet batch size of 300g) [A-006]
    Aqueous enteric coating for lansoprazole using Shin-Etsu AQOAT® (HPMCAS) [A-059]
    Aqueous enteric coating for soft gelatin capsule using Shin-Etsu AQOAT® (HPMCAS) [A-043]
    Aqueous enteric coating for soft gelatin capsule with Shin-Etsu AQOAT® (HPMCAS) [A-062]
    Aqueous enteric coating using Shin-Etsu AQOAT® (HPMCAS) for Mini-Tablets [A-053]
    Aqueous enteric coating with Shin-Etsu AQOAT® (HPMCAS): ammonia-neutralized method - part 1: solution and film properties [A-008]
    Aqueous enteric coating with Shin-Etsu AQOAT® (HPMCAS): ammonia-neutralized method - part 2: examples of coating applications [A-012]
    Aqueous enteric coating with Shin-Etsu AQOAT® (HPMCAS): ammonia-neutralized method - part 3: stability of the coated preparations [A-013]
    Aqueous fine particle coating with angled spray [A-044]
    Aqueous formulation of Shin-Etsu AQOAT® (HPMCAS) containing an amino acid as stabilizer - comparison of formulation and process parameters on different coating equipment [A-055]
    Comparative study of various coating methods with Shin-Etsu AQOAT® (HPMCAS) for pellets [A-060]
    Comparison of mini-tablets enteric coating with Shin-Etsu AQOAT® (HPMCAS) using perforated pan or fluid bed coating equipment [A-056]
    Concentration - viscosity curve of Shin-Etsu AQOAT® (HPMCAS) [A-064]
    Direct compression of spray dried dispersion [A-072]
    Dissolution behavior of coated fine particles by aqueous and solvent coating [A-045, H-013]
    Effect of hot melt extrusion on the physicochemical properties of Shin-Etsu AQOAT® (HPMCAS) [A-017]
    Effect of substitution of Shin-Etsu AQOAT® (HPMCAS) on dissolution profile of nifedipine solid dispersions (SD) prepared by Hot Melt Extrusion [A-032]
    Enteric coating of hard gelatin capsules using Shin-Etsu AQOAT® (HPMCAS) [A-029]
    Enteric coating of omeprazol granules using Shin-Etsu AQOAT® (HPMCAS) [A-031]
    Enteric coating with Shin-Etsu AQOAT® (HPMCAS) by using water-ethanol solution [A-004]
    Examples of aqueous dispersion coating using Shin-Etsu AQOAT® (HPMCAS) [A-003]
    Impact of process parameters to solid dispersion particles [A-071]
    Influence of alcohol on gastric resistance of Shin-Etsu AQOAT® (HPMCAS) [A-014]
    IR spectrums of HPMCP and Shin-Etsu AQOAT® [H-017, A-054]
    Mechanical properties of hot melt extruded amorphous solid dispersion with Shin-Etsu AQOAT® (HPMCAS) [A-073]
    Milling and downstream processing of hot melt extruded (HME) amorphous solid dispersion with Shin-Etsu AQOAT® (HPMCAS) [A-067]
    Minimum film formation temperature of Shin-Etsu AQOAT® (HPMCAS) (2) [A-047]
    Minimum film formation temperature of Shin-Etsu AQOAT® (HPMCAS) [A-005]
    Molecular weight of Shin-Etsu AQOAT® (HPMCAS) [A-007]
    Nifedipine solid dispersion using Shin-Etsu AQOAT® - preparation by HME and downstream processing [A-051]
    Partially neutralized coating technique using Shin-Etsu AQOAT® (HPMCAS) [A-037]
    Scale-up of tablet enteric coating using the partially ammonia neutralized Shin-Etsu AQOAT® (HPMCAS) dispersion [A-068]
    Solid dispersions (SD) using Shin-Etsu AQOAT® (HPMCAS) by holt melt extrusion [A-018]
    Solubility of Shin-Etsu AQOAT® (HPMCAS) in alkali solutions for cleaning media after coating operations [A-021]
    Solubility of Shin-Etsu AQOAT® (HPMCAS) in mixed organic solvents [A-035]
    Solution preparation of HPMCP and Shin-Etsu AQOAT® (HPMCAS) [H-019, A-058]
    Stability of Shin-Etsu AQOAT® (HPMCAS) at high temperatures [A-010]
    Taste masking coating for quinine tablets [A-061]
    Taste masking coating using Shin-Etsu AQOAT® (HPMCAS) and PHARMACOAT® with controlled release [A-063, P-018]
    Triacetin as an alternative plasticizer for aqueous dispersion with Shin-Etsu AQOAT® (HPMCAS) [A-057]
    Shin-Etsu AQOAT® AS-HMP HPMCAS, 200 µm, opening pH>6.5NF, JPJapan Very suitable Select
    Related documentsLanguagesAvailable as Download or Request
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    Guide to Applications
    Pharmaceutical Excipients
    Shin-Etsu AQOAT®
    Safety Data Sheets
    Safety Data Sheet
    Technical Information
    3D printing tablets with Shin-Etsu AQOAT® (HPMCAS) [A-069]
    Application of Shin-Etsu AQOAT® (HPMCAS) as a carrier in solid dispersion [A-028]
    Application of Shin-Etsu AQOAT® (HPMCAS) in extended release (ER) matrix tablet formulation [A-070]
    Aqueous based enteric formulation of Shin-Etsu AQOAT® (HPMCAS) containing amino acid as a stabilizer [A-049]
    Aqueous dispersion coating using Shin-Etsu AQOAT® (HPMCAS) (Coating parameters of a tablet batch size 5-100kg) [A-002]
    Aqueous dispersion coating using Shin-Etsu AQOAT® (HPMCAS) (Preparation of coating dispersion) [A-001]
    Aqueous dispersion coating using Shin-Etsu AQOAT® (HPMCAS) (Using a small tabletop coating machine we coated tablet batch size of 300g) [A-006]
    Aqueous enteric coating for lansoprazole using Shin-Etsu AQOAT® (HPMCAS) [A-059]
    Aqueous enteric coating for soft gelatin capsule using Shin-Etsu AQOAT® (HPMCAS) [A-043]
    Aqueous enteric coating for soft gelatin capsule with Shin-Etsu AQOAT® (HPMCAS) [A-062]
    Aqueous enteric coating using Shin-Etsu AQOAT® (HPMCAS) for Mini-Tablets [A-053]
    Aqueous enteric coating with Shin-Etsu AQOAT® (HPMCAS): ammonia-neutralized method - part 1: solution and film properties [A-008]
    Aqueous enteric coating with Shin-Etsu AQOAT® (HPMCAS): ammonia-neutralized method - part 2: examples of coating applications [A-012]
    Aqueous enteric coating with Shin-Etsu AQOAT® (HPMCAS): ammonia-neutralized method - part 3: stability of the coated preparations [A-013]
    Aqueous fine particle coating with angled spray [A-044]
    Aqueous formulation of Shin-Etsu AQOAT® (HPMCAS) containing an amino acid as stabilizer - comparison of formulation and process parameters on different coating equipment [A-055]
    Comparative study of various coating methods with Shin-Etsu AQOAT® (HPMCAS) for pellets [A-060]
    Comparison of mini-tablets enteric coating with Shin-Etsu AQOAT® (HPMCAS) using perforated pan or fluid bed coating equipment [A-056]
    Concentration - viscosity curve of Shin-Etsu AQOAT® (HPMCAS) [A-064]
    Direct compression of spray dried dispersion [A-072]
    Dissolution behavior of coated fine particles by aqueous and solvent coating [A-045, H-013]
    Effect of hot melt extrusion on the physicochemical properties of Shin-Etsu AQOAT® (HPMCAS) [A-017]
    Effect of substitution of Shin-Etsu AQOAT® (HPMCAS) on dissolution profile of nifedipine solid dispersions (SD) prepared by Hot Melt Extrusion [A-032]
    Enteric coating of hard gelatin capsules using Shin-Etsu AQOAT® (HPMCAS) [A-029]
    Enteric coating of omeprazol granules using Shin-Etsu AQOAT® (HPMCAS) [A-031]
    Enteric coating with Shin-Etsu AQOAT® (HPMCAS) by using water-ethanol solution [A-004]
    Examples of aqueous dispersion coating using Shin-Etsu AQOAT® (HPMCAS) [A-003]
    Impact of process parameters to solid dispersion particles [A-071]
    Influence of alcohol on gastric resistance of Shin-Etsu AQOAT® (HPMCAS) [A-014]
    IR spectrums of HPMCP and Shin-Etsu AQOAT® [H-017, A-054]
    Mechanical properties of hot melt extruded amorphous solid dispersion with Shin-Etsu AQOAT® (HPMCAS) [A-073]
    Milling and downstream processing of hot melt extruded (HME) amorphous solid dispersion with Shin-Etsu AQOAT® (HPMCAS) [A-067]
    Minimum film formation temperature of Shin-Etsu AQOAT® (HPMCAS) (2) [A-047]
    Minimum film formation temperature of Shin-Etsu AQOAT® (HPMCAS) [A-005]
    Molecular weight of Shin-Etsu AQOAT® (HPMCAS) [A-007]
    Nifedipine solid dispersion using Shin-Etsu AQOAT® - preparation by HME and downstream processing [A-051]
    Partially neutralized coating technique using Shin-Etsu AQOAT® (HPMCAS) [A-037]
    Scale-up of tablet enteric coating using the partially ammonia neutralized Shin-Etsu AQOAT® (HPMCAS) dispersion [A-068]
    Solid dispersions (SD) using Shin-Etsu AQOAT® (HPMCAS) by holt melt extrusion [A-018]
    Solubility of Shin-Etsu AQOAT® (HPMCAS) in alkali solutions for cleaning media after coating operations [A-021]
    Solubility of Shin-Etsu AQOAT® (HPMCAS) in mixed organic solvents [A-035]
    Solution preparation of HPMCP and Shin-Etsu AQOAT® (HPMCAS) [H-019, A-058]
    Stability of Shin-Etsu AQOAT® (HPMCAS) at high temperatures [A-010]
    Taste masking coating for quinine tablets [A-061]
    Taste masking coating using Shin-Etsu AQOAT® (HPMCAS) and PHARMACOAT® with controlled release [A-063, P-018]
    Triacetin as an alternative plasticizer for aqueous dispersion with Shin-Etsu AQOAT® (HPMCAS) [A-057]
    Shin-Etsu AQOAT® AS-LG HPMCAS, 1000 µm, opening pH>5.5NF, JPJapan Suitable Select
    Related documentsLanguagesAvailable as Download or Request
    Brochures
    Guide to Applications
    Pharmaceutical Excipients
    Shin-Etsu AQOAT®
    Safety Data Sheets
    Safety Data Sheet
    Technical Information
    3D printing tablets with Shin-Etsu AQOAT® (HPMCAS) [A-069]
    Application of Shin-Etsu AQOAT® (HPMCAS) as a carrier in solid dispersion [A-028]
    Application of Shin-Etsu AQOAT® (HPMCAS) in extended release (ER) matrix tablet formulation [A-070]
    Aqueous based enteric formulation of Shin-Etsu AQOAT® (HPMCAS) containing amino acid as a stabilizer [A-049]
    Aqueous dispersion coating using Shin-Etsu AQOAT® (HPMCAS) (Coating parameters of a tablet batch size 5-100kg) [A-002]
    Aqueous dispersion coating using Shin-Etsu AQOAT® (HPMCAS) (Preparation of coating dispersion) [A-001]
    Aqueous dispersion coating using Shin-Etsu AQOAT® (HPMCAS) (Using a small tabletop coating machine we coated tablet batch size of 300g) [A-006]
    Aqueous enteric coating for lansoprazole using Shin-Etsu AQOAT® (HPMCAS) [A-059]
    Aqueous enteric coating for soft gelatin capsule using Shin-Etsu AQOAT® (HPMCAS) [A-043]
    Aqueous enteric coating for soft gelatin capsule with Shin-Etsu AQOAT® (HPMCAS) [A-062]
    Aqueous enteric coating using Shin-Etsu AQOAT® (HPMCAS) for Mini-Tablets [A-053]
    Aqueous enteric coating with Shin-Etsu AQOAT® (HPMCAS): ammonia-neutralized method - part 1: solution and film properties [A-008]
    Aqueous enteric coating with Shin-Etsu AQOAT® (HPMCAS): ammonia-neutralized method - part 2: examples of coating applications [A-012]
    Aqueous enteric coating with Shin-Etsu AQOAT® (HPMCAS): ammonia-neutralized method - part 3: stability of the coated preparations [A-013]
    Aqueous fine particle coating with angled spray [A-044]
    Aqueous formulation of Shin-Etsu AQOAT® (HPMCAS) containing an amino acid as stabilizer - comparison of formulation and process parameters on different coating equipment [A-055]
    Comparative study of various coating methods with Shin-Etsu AQOAT® (HPMCAS) for pellets [A-060]
    Comparison of mini-tablets enteric coating with Shin-Etsu AQOAT® (HPMCAS) using perforated pan or fluid bed coating equipment [A-056]
    Concentration - viscosity curve of Shin-Etsu AQOAT® (HPMCAS) [A-064]
    Direct compression of spray dried dispersion [A-072]
    Dissolution behavior of coated fine particles by aqueous and solvent coating [A-045, H-013]
    Effect of hot melt extrusion on the physicochemical properties of Shin-Etsu AQOAT® (HPMCAS) [A-017]
    Effect of substitution of Shin-Etsu AQOAT® (HPMCAS) on dissolution profile of nifedipine solid dispersions (SD) prepared by Hot Melt Extrusion [A-032]
    Enteric coating of hard gelatin capsules using Shin-Etsu AQOAT® (HPMCAS) [A-029]
    Enteric coating of omeprazol granules using Shin-Etsu AQOAT® (HPMCAS) [A-031]
    Enteric coating with Shin-Etsu AQOAT® (HPMCAS) by using water-ethanol solution [A-004]
    Examples of aqueous dispersion coating using Shin-Etsu AQOAT® (HPMCAS) [A-003]
    Impact of process parameters to solid dispersion particles [A-071]
    Influence of alcohol on gastric resistance of Shin-Etsu AQOAT® (HPMCAS) [A-014]
    IR spectrums of HPMCP and Shin-Etsu AQOAT® [H-017, A-054]
    Mechanical properties of hot melt extruded amorphous solid dispersion with Shin-Etsu AQOAT® (HPMCAS) [A-073]
    Milling and downstream processing of hot melt extruded (HME) amorphous solid dispersion with Shin-Etsu AQOAT® (HPMCAS) [A-067]
    Minimum film formation temperature of Shin-Etsu AQOAT® (HPMCAS) (2) [A-047]
    Minimum film formation temperature of Shin-Etsu AQOAT® (HPMCAS) [A-005]
    Molecular weight of Shin-Etsu AQOAT® (HPMCAS) [A-007]
    Nifedipine solid dispersion using Shin-Etsu AQOAT® - preparation by HME and downstream processing [A-051]
    Partially neutralized coating technique using Shin-Etsu AQOAT® (HPMCAS) [A-037]
    Scale-up of tablet enteric coating using the partially ammonia neutralized Shin-Etsu AQOAT® (HPMCAS) dispersion [A-068]
    Solid dispersions (SD) using Shin-Etsu AQOAT® (HPMCAS) by holt melt extrusion [A-018]
    Solubility of Shin-Etsu AQOAT® (HPMCAS) in alkali solutions for cleaning media after coating operations [A-021]
    Solubility of Shin-Etsu AQOAT® (HPMCAS) in mixed organic solvents [A-035]
    Solution preparation of HPMCP and Shin-Etsu AQOAT® (HPMCAS) [H-019, A-058]
    Stability of Shin-Etsu AQOAT® (HPMCAS) at high temperatures [A-010]
    Taste masking coating for quinine tablets [A-061]
    Taste masking coating using Shin-Etsu AQOAT® (HPMCAS) and PHARMACOAT® with controlled release [A-063, P-018]
    Triacetin as an alternative plasticizer for aqueous dispersion with Shin-Etsu AQOAT® (HPMCAS) [A-057]
    Shin-Etsu AQOAT® AS-MG HPMCAS, 1000 µm, opening pH>6.0NF, JPJapan Suitable Select
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    Technical Information
    3D printing tablets with Shin-Etsu AQOAT® (HPMCAS) [A-069]
    Application of Shin-Etsu AQOAT® (HPMCAS) as a carrier in solid dispersion [A-028]
    Application of Shin-Etsu AQOAT® (HPMCAS) in extended release (ER) matrix tablet formulation [A-070]
    Aqueous based enteric formulation of Shin-Etsu AQOAT® (HPMCAS) containing amino acid as a stabilizer [A-049]
    Aqueous dispersion coating using Shin-Etsu AQOAT® (HPMCAS) (Coating parameters of a tablet batch size 5-100kg) [A-002]
    Aqueous dispersion coating using Shin-Etsu AQOAT® (HPMCAS) (Preparation of coating dispersion) [A-001]
    Aqueous dispersion coating using Shin-Etsu AQOAT® (HPMCAS) (Using a small tabletop coating machine we coated tablet batch size of 300g) [A-006]
    Aqueous enteric coating for lansoprazole using Shin-Etsu AQOAT® (HPMCAS) [A-059]
    Aqueous enteric coating for soft gelatin capsule using Shin-Etsu AQOAT® (HPMCAS) [A-043]
    Aqueous enteric coating for soft gelatin capsule with Shin-Etsu AQOAT® (HPMCAS) [A-062]
    Aqueous enteric coating using Shin-Etsu AQOAT® (HPMCAS) for Mini-Tablets [A-053]
    Aqueous enteric coating with Shin-Etsu AQOAT® (HPMCAS): ammonia-neutralized method - part 1: solution and film properties [A-008]
    Aqueous enteric coating with Shin-Etsu AQOAT® (HPMCAS): ammonia-neutralized method - part 2: examples of coating applications [A-012]
    Aqueous enteric coating with Shin-Etsu AQOAT® (HPMCAS): ammonia-neutralized method - part 3: stability of the coated preparations [A-013]
    Aqueous fine particle coating with angled spray [A-044]
    Aqueous formulation of Shin-Etsu AQOAT® (HPMCAS) containing an amino acid as stabilizer - comparison of formulation and process parameters on different coating equipment [A-055]
    Comparative study of various coating methods with Shin-Etsu AQOAT® (HPMCAS) for pellets [A-060]
    Comparison of mini-tablets enteric coating with Shin-Etsu AQOAT® (HPMCAS) using perforated pan or fluid bed coating equipment [A-056]
    Concentration - viscosity curve of Shin-Etsu AQOAT® (HPMCAS) [A-064]
    Direct compression of spray dried dispersion [A-072]
    Dissolution behavior of coated fine particles by aqueous and solvent coating [A-045, H-013]
    Effect of hot melt extrusion on the physicochemical properties of Shin-Etsu AQOAT® (HPMCAS) [A-017]
    Effect of substitution of Shin-Etsu AQOAT® (HPMCAS) on dissolution profile of nifedipine solid dispersions (SD) prepared by Hot Melt Extrusion [A-032]
    Enteric coating of hard gelatin capsules using Shin-Etsu AQOAT® (HPMCAS) [A-029]
    Enteric coating of omeprazol granules using Shin-Etsu AQOAT® (HPMCAS) [A-031]
    Enteric coating with Shin-Etsu AQOAT® (HPMCAS) by using water-ethanol solution [A-004]
    Examples of aqueous dispersion coating using Shin-Etsu AQOAT® (HPMCAS) [A-003]
    Impact of process parameters to solid dispersion particles [A-071]
    Influence of alcohol on gastric resistance of Shin-Etsu AQOAT® (HPMCAS) [A-014]
    IR spectrums of HPMCP and Shin-Etsu AQOAT® [H-017, A-054]
    Mechanical properties of hot melt extruded amorphous solid dispersion with Shin-Etsu AQOAT® (HPMCAS) [A-073]
    Milling and downstream processing of hot melt extruded (HME) amorphous solid dispersion with Shin-Etsu AQOAT® (HPMCAS) [A-067]
    Minimum film formation temperature of Shin-Etsu AQOAT® (HPMCAS) (2) [A-047]
    Minimum film formation temperature of Shin-Etsu AQOAT® (HPMCAS) [A-005]
    Molecular weight of Shin-Etsu AQOAT® (HPMCAS) [A-007]
    Nifedipine solid dispersion using Shin-Etsu AQOAT® - preparation by HME and downstream processing [A-051]
    Partially neutralized coating technique using Shin-Etsu AQOAT® (HPMCAS) [A-037]
    Scale-up of tablet enteric coating using the partially ammonia neutralized Shin-Etsu AQOAT® (HPMCAS) dispersion [A-068]
    Solid dispersions (SD) using Shin-Etsu AQOAT® (HPMCAS) by holt melt extrusion [A-018]
    Solubility of Shin-Etsu AQOAT® (HPMCAS) in alkali solutions for cleaning media after coating operations [A-021]
    Solubility of Shin-Etsu AQOAT® (HPMCAS) in mixed organic solvents [A-035]
    Solution preparation of HPMCP and Shin-Etsu AQOAT® (HPMCAS) [H-019, A-058]
    Stability of Shin-Etsu AQOAT® (HPMCAS) at high temperatures [A-010]
    Taste masking coating for quinine tablets [A-061]
    Taste masking coating using Shin-Etsu AQOAT® (HPMCAS) and PHARMACOAT® with controlled release [A-063, P-018]
    Triacetin as an alternative plasticizer for aqueous dispersion with Shin-Etsu AQOAT® (HPMCAS) [A-057]
    Shin-Etsu AQOAT® AS-HG HPMCAS, 1000 µm, opening pH>6.5NF, JPJapan Suitable Select
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    3D printing tablets with Shin-Etsu AQOAT® (HPMCAS) [A-069]
    Application of Shin-Etsu AQOAT® (HPMCAS) as a carrier in solid dispersion [A-028]
    Application of Shin-Etsu AQOAT® (HPMCAS) in extended release (ER) matrix tablet formulation [A-070]
    Aqueous based enteric formulation of Shin-Etsu AQOAT® (HPMCAS) containing amino acid as a stabilizer [A-049]
    Aqueous dispersion coating using Shin-Etsu AQOAT® (HPMCAS) (Coating parameters of a tablet batch size 5-100kg) [A-002]
    Aqueous dispersion coating using Shin-Etsu AQOAT® (HPMCAS) (Preparation of coating dispersion) [A-001]
    Aqueous dispersion coating using Shin-Etsu AQOAT® (HPMCAS) (Using a small tabletop coating machine we coated tablet batch size of 300g) [A-006]
    Aqueous enteric coating for lansoprazole using Shin-Etsu AQOAT® (HPMCAS) [A-059]
    Aqueous enteric coating for soft gelatin capsule using Shin-Etsu AQOAT® (HPMCAS) [A-043]
    Aqueous enteric coating for soft gelatin capsule with Shin-Etsu AQOAT® (HPMCAS) [A-062]
    Aqueous enteric coating using Shin-Etsu AQOAT® (HPMCAS) for Mini-Tablets [A-053]
    Aqueous enteric coating with Shin-Etsu AQOAT® (HPMCAS): ammonia-neutralized method - part 1: solution and film properties [A-008]
    Aqueous enteric coating with Shin-Etsu AQOAT® (HPMCAS): ammonia-neutralized method - part 2: examples of coating applications [A-012]
    Aqueous enteric coating with Shin-Etsu AQOAT® (HPMCAS): ammonia-neutralized method - part 3: stability of the coated preparations [A-013]
    Aqueous fine particle coating with angled spray [A-044]
    Aqueous formulation of Shin-Etsu AQOAT® (HPMCAS) containing an amino acid as stabilizer - comparison of formulation and process parameters on different coating equipment [A-055]
    Comparative study of various coating methods with Shin-Etsu AQOAT® (HPMCAS) for pellets [A-060]
    Comparison of mini-tablets enteric coating with Shin-Etsu AQOAT® (HPMCAS) using perforated pan or fluid bed coating equipment [A-056]
    Concentration - viscosity curve of Shin-Etsu AQOAT® (HPMCAS) [A-064]
    Direct compression of spray dried dispersion [A-072]
    Dissolution behavior of coated fine particles by aqueous and solvent coating [A-045, H-013]
    Effect of hot melt extrusion on the physicochemical properties of Shin-Etsu AQOAT® (HPMCAS) [A-017]
    Effect of substitution of Shin-Etsu AQOAT® (HPMCAS) on dissolution profile of nifedipine solid dispersions (SD) prepared by Hot Melt Extrusion [A-032]
    Enteric coating of hard gelatin capsules using Shin-Etsu AQOAT® (HPMCAS) [A-029]
    Enteric coating of omeprazol granules using Shin-Etsu AQOAT® (HPMCAS) [A-031]
    Enteric coating with Shin-Etsu AQOAT® (HPMCAS) by using water-ethanol solution [A-004]
    Examples of aqueous dispersion coating using Shin-Etsu AQOAT® (HPMCAS) [A-003]
    Impact of process parameters to solid dispersion particles [A-071]
    Influence of alcohol on gastric resistance of Shin-Etsu AQOAT® (HPMCAS) [A-014]
    IR spectrums of HPMCP and Shin-Etsu AQOAT® [H-017, A-054]
    Mechanical properties of hot melt extruded amorphous solid dispersion with Shin-Etsu AQOAT® (HPMCAS) [A-073]
    Milling and downstream processing of hot melt extruded (HME) amorphous solid dispersion with Shin-Etsu AQOAT® (HPMCAS) [A-067]
    Minimum film formation temperature of Shin-Etsu AQOAT® (HPMCAS) (2) [A-047]
    Minimum film formation temperature of Shin-Etsu AQOAT® (HPMCAS) [A-005]
    Molecular weight of Shin-Etsu AQOAT® (HPMCAS) [A-007]
    Nifedipine solid dispersion using Shin-Etsu AQOAT® - preparation by HME and downstream processing [A-051]
    Partially neutralized coating technique using Shin-Etsu AQOAT® (HPMCAS) [A-037]
    Scale-up of tablet enteric coating using the partially ammonia neutralized Shin-Etsu AQOAT® (HPMCAS) dispersion [A-068]
    Solid dispersions (SD) using Shin-Etsu AQOAT® (HPMCAS) by holt melt extrusion [A-018]
    Solubility of Shin-Etsu AQOAT® (HPMCAS) in alkali solutions for cleaning media after coating operations [A-021]
    Solubility of Shin-Etsu AQOAT® (HPMCAS) in mixed organic solvents [A-035]
    Solution preparation of HPMCP and Shin-Etsu AQOAT® (HPMCAS) [H-019, A-058]
    Stability of Shin-Etsu AQOAT® (HPMCAS) at high temperatures [A-010]
    Taste masking coating for quinine tablets [A-061]
    Taste masking coating using Shin-Etsu AQOAT® (HPMCAS) and PHARMACOAT® with controlled release [A-063, P-018]
    Triacetin as an alternative plasticizer for aqueous dispersion with Shin-Etsu AQOAT® (HPMCAS) [A-057]
    TYLOPUR® 603 Hypromellose 2910, 3 mPasUSP, EP, JP, EXCiPACTGermany Very suitable Select
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    TYLOPUR® 645 Hypromellose 2910, 4.5 mPasUSP, EP, JP, EXCiPACTGermany Very suitable Select
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    TYLOPUR® 605 Hypromellose 2910, 5 mPasUSP, EP, JP, EXCiPACTGermany Suitable Select
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    TYLOPUR® 606 Hypromellose 2910, 6 mPasUSP, EP, JP, EXCiPACTGermany Suitable Select
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    Solvent methods

    Amorphous solid dispersions are also accessible by dissolving API and polymer carrier in a common organic solvent. Upon removal of the solvent, the dry product contains polymer with molecular dispersed, amorphous API. Processes examples utilizing organic solvents are spray drying, spray coating or co-precipitation.

    Recommended products

    GradesDescriptionPharmacopoeiaOriginRecommendationKnowledge Base
    PHARMACOAT® 603 Hypromellose 2910, 3 mPasUSP, EP, JPJapan Very suitable Select
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    A coating technique for high-friability tablets using PHARMACOAT® [P-011]
    An advanced coating formulation with PVA and HPMC [P-012]
    An organic coating method with PHARMACOAT®, with mixed solvent of high content of ethanol and water [P-009]
    Application of L-HPC and PHARMACOAT® in twin screw granulation for continuous manufacturing [L-039]
    Application of PHARMACOAT® as a carrier in solid dispersion [P-010]
    Coating formulation for logo tablets [P-013]
    Comparative study of wet granulation binders [P-017]
    Dissolution behavior of various HPMC lower viscosity grades [P-014]
    Effect of moisture content on the mechanical properties of cast HPMC films [P-005]
    Effect of plasticizers and other additives on the mechanical properties of cast HPMC films [P-008]
    Film properties of HPMC and MC [G-002]
    Film properties of low-viscosity grade cellulose derivatives [G-011]
    Oxygen permeability of low-viscosity grade cellulose derivatives [G-016]
    Taste masking coating using Shin-Etsu AQOAT® and PHARMACOAT® with controlled release [A-63, P-018]
    PHARMACOAT® 645 Hypromellose 2910, 4.5 mPasUSP, EP, JPJapan Very suitable Select
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    An advanced coating formulation with PVA and HPMC [P-012]
    An organic coating method with PHARMACOAT®, with mixed solvent of high content of ethanol and water [P-009]
    Application of L-HPC and PHARMACOAT® in twin screw granulation for continuous manufacturing [L-039]
    Application of PHARMACOAT® as a carrier in solid dispersion [P-010]
    Coating formulation for logo tablets [P-013]
    Comparative study of wet granulation binders [P-017]
    Dissolution behavior of various HPMC lower viscosity grades [P-014]
    Effect of moisture content on the mechanical properties of cast HPMC films [P-005]
    Effect of plasticizers and other additives on the mechanical properties of cast HPMC films [P-008]
    Film properties of HPMC and MC [G-002]
    Film properties of low-viscosity grade cellulose derivatives [G-011]
    Taste masking coating using Shin-Etsu AQOAT® and PHARMACOAT® with controlled release [A-63, P-018]
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    An advanced coating formulation with PVA and HPMC [P-012]
    An organic coating method with PHARMACOAT®, with mixed solvent of high content of ethanol and water [P-009]
    Application of L-HPC and PHARMACOAT® in twin screw granulation for continuous manufacturing [L-039]
    Application of PHARMACOAT® as a carrier in solid dispersion [P-010]
    Coating formulation for logo tablets [P-013]
    Comparative study of wet granulation binders [P-017]
    Dissolution behavior of various HPMC lower viscosity grades [P-014]
    Effect of moisture content on the mechanical properties of cast HPMC films [P-005]
    Effect of plasticizers and other additives on the mechanical properties of cast HPMC films [P-008]
    Film properties of HPMC and MC [G-002]
    Film properties of low-viscosity grade cellulose derivatives [G-011]
    Oxygen permeability of low-viscosity grade cellulose derivatives [G-016]
    Solubility of PHARMACOAT® 606 in acetone/water mixtures [P-016]
    Solubility of PHARMACOAT® 606 in alcohol-water mixtures [P-004]
    Taste masking coating using Shin-Etsu AQOAT® and PHARMACOAT® with controlled release [A-63, P-018]
    HPMCP All Grades Different grades, opening >pH 5.0 - 5.5NF, EP, JPJapan Very suitable Select
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    Application of HPMCP in extended release matrix tablet formulation [H-023]
    Application of HPMCP in the development of rabeprazole sodium delayed release tablet by organic enteric coating [H-022]
    Dissolution behavior of coated fine particles by aqueous and solvent coating [A-045, H-013]
    Enteric coating of hard gelatin capsules using HPMCP [H-006]
    Enteric coating of soft gelatin capsules with HPMCP [H-018]
    Film solubility of mixed HPMCP [H-011]
    HPMCP - typical coating conditions for tablets (1) [H-002]
    HPMCP - typical coating conditions for tablets (2) [H-003]
    HPMCP - typical coating conditions for tablets [H-001]
    Hydrolysis of HPMCP in ethanol-water solution [H-005]
    IR spectrums of HPMCP and Shin-Etsu AQOAT® [H-017, A-054]
    Itraconazole 65 mg capsule using HPMPC-50 by solid dispersion approach [H-021]
    Residual solvent in ethanol/water HPMPC-55 tablet coating [H-007]
    Solubility of HPMCP in mixed organic solvents [H-010]
    Solution preparation of HPMCP and Shin-Etsu AQOAT® (HPMCAS) [H-019, A-058]
    Stability of HPMCP coated tablets [H-015]
    Stability of HPMCP under humid storage conditions [H-016]
    Shin-Etsu AQOAT® AS-LG HPMCAS, 1000 µm, opening pH>5.5NF, JPJapan Very suitable Select
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    Application of Shin-Etsu AQOAT® (HPMCAS) as a carrier in solid dispersion [A-028]
    Application of Shin-Etsu AQOAT® (HPMCAS) in extended release (ER) matrix tablet formulation [A-070]
    Aqueous based enteric formulation of Shin-Etsu AQOAT® (HPMCAS) containing amino acid as a stabilizer [A-049]
    Aqueous dispersion coating using Shin-Etsu AQOAT® (HPMCAS) (Coating parameters of a tablet batch size 5-100kg) [A-002]
    Aqueous dispersion coating using Shin-Etsu AQOAT® (HPMCAS) (Preparation of coating dispersion) [A-001]
    Aqueous dispersion coating using Shin-Etsu AQOAT® (HPMCAS) (Using a small tabletop coating machine we coated tablet batch size of 300g) [A-006]
    Aqueous enteric coating for lansoprazole using Shin-Etsu AQOAT® (HPMCAS) [A-059]
    Aqueous enteric coating for soft gelatin capsule using Shin-Etsu AQOAT® (HPMCAS) [A-043]
    Aqueous enteric coating for soft gelatin capsule with Shin-Etsu AQOAT® (HPMCAS) [A-062]
    Aqueous enteric coating using Shin-Etsu AQOAT® (HPMCAS) for Mini-Tablets [A-053]
    Aqueous enteric coating with Shin-Etsu AQOAT® (HPMCAS): ammonia-neutralized method - part 1: solution and film properties [A-008]
    Aqueous enteric coating with Shin-Etsu AQOAT® (HPMCAS): ammonia-neutralized method - part 2: examples of coating applications [A-012]
    Aqueous enteric coating with Shin-Etsu AQOAT® (HPMCAS): ammonia-neutralized method - part 3: stability of the coated preparations [A-013]
    Aqueous fine particle coating with angled spray [A-044]
    Aqueous formulation of Shin-Etsu AQOAT® (HPMCAS) containing an amino acid as stabilizer - comparison of formulation and process parameters on different coating equipment [A-055]
    Comparative study of various coating methods with Shin-Etsu AQOAT® (HPMCAS) for pellets [A-060]
    Comparison of mini-tablets enteric coating with Shin-Etsu AQOAT® (HPMCAS) using perforated pan or fluid bed coating equipment [A-056]
    Concentration - viscosity curve of Shin-Etsu AQOAT® (HPMCAS) [A-064]
    Direct compression of spray dried dispersion [A-072]
    Dissolution behavior of coated fine particles by aqueous and solvent coating [A-045, H-013]
    Effect of hot melt extrusion on the physicochemical properties of Shin-Etsu AQOAT® (HPMCAS) [A-017]
    Effect of substitution of Shin-Etsu AQOAT® (HPMCAS) on dissolution profile of nifedipine solid dispersions (SD) prepared by Hot Melt Extrusion [A-032]
    Enteric coating of hard gelatin capsules using Shin-Etsu AQOAT® (HPMCAS) [A-029]
    Enteric coating of omeprazol granules using Shin-Etsu AQOAT® (HPMCAS) [A-031]
    Enteric coating with Shin-Etsu AQOAT® (HPMCAS) by using water-ethanol solution [A-004]
    Examples of aqueous dispersion coating using Shin-Etsu AQOAT® (HPMCAS) [A-003]
    Impact of process parameters to solid dispersion particles [A-071]
    Influence of alcohol on gastric resistance of Shin-Etsu AQOAT® (HPMCAS) [A-014]
    IR spectrums of HPMCP and Shin-Etsu AQOAT® [H-017, A-054]
    Mechanical properties of hot melt extruded amorphous solid dispersion with Shin-Etsu AQOAT® (HPMCAS) [A-073]
    Milling and downstream processing of hot melt extruded (HME) amorphous solid dispersion with Shin-Etsu AQOAT® (HPMCAS) [A-067]
    Minimum film formation temperature of Shin-Etsu AQOAT® (HPMCAS) (2) [A-047]
    Minimum film formation temperature of Shin-Etsu AQOAT® (HPMCAS) [A-005]
    Molecular weight of Shin-Etsu AQOAT® (HPMCAS) [A-007]
    Nifedipine solid dispersion using Shin-Etsu AQOAT® - preparation by HME and downstream processing [A-051]
    Partially neutralized coating technique using Shin-Etsu AQOAT® (HPMCAS) [A-037]
    Scale-up of tablet enteric coating using the partially ammonia neutralized Shin-Etsu AQOAT® (HPMCAS) dispersion [A-068]
    Solid dispersions (SD) using Shin-Etsu AQOAT® (HPMCAS) by holt melt extrusion [A-018]
    Solubility of Shin-Etsu AQOAT® (HPMCAS) in alkali solutions for cleaning media after coating operations [A-021]
    Solubility of Shin-Etsu AQOAT® (HPMCAS) in mixed organic solvents [A-035]
    Solution preparation of HPMCP and Shin-Etsu AQOAT® (HPMCAS) [H-019, A-058]
    Stability of Shin-Etsu AQOAT® (HPMCAS) at high temperatures [A-010]
    Taste masking coating for quinine tablets [A-061]
    Taste masking coating using Shin-Etsu AQOAT® (HPMCAS) and PHARMACOAT® with controlled release [A-063, P-018]
    Triacetin as an alternative plasticizer for aqueous dispersion with Shin-Etsu AQOAT® (HPMCAS) [A-057]
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    3D printing tablets with Shin-Etsu AQOAT® (HPMCAS) [A-069]
    Application of Shin-Etsu AQOAT® (HPMCAS) as a carrier in solid dispersion [A-028]
    Application of Shin-Etsu AQOAT® (HPMCAS) in extended release (ER) matrix tablet formulation [A-070]
    Aqueous based enteric formulation of Shin-Etsu AQOAT® (HPMCAS) containing amino acid as a stabilizer [A-049]
    Aqueous dispersion coating using Shin-Etsu AQOAT® (HPMCAS) (Coating parameters of a tablet batch size 5-100kg) [A-002]
    Aqueous dispersion coating using Shin-Etsu AQOAT® (HPMCAS) (Preparation of coating dispersion) [A-001]
    Aqueous dispersion coating using Shin-Etsu AQOAT® (HPMCAS) (Using a small tabletop coating machine we coated tablet batch size of 300g) [A-006]
    Aqueous enteric coating for lansoprazole using Shin-Etsu AQOAT® (HPMCAS) [A-059]
    Aqueous enteric coating for soft gelatin capsule using Shin-Etsu AQOAT® (HPMCAS) [A-043]
    Aqueous enteric coating for soft gelatin capsule with Shin-Etsu AQOAT® (HPMCAS) [A-062]
    Aqueous enteric coating using Shin-Etsu AQOAT® (HPMCAS) for Mini-Tablets [A-053]
    Aqueous enteric coating with Shin-Etsu AQOAT® (HPMCAS): ammonia-neutralized method - part 1: solution and film properties [A-008]
    Aqueous enteric coating with Shin-Etsu AQOAT® (HPMCAS): ammonia-neutralized method - part 2: examples of coating applications [A-012]
    Aqueous enteric coating with Shin-Etsu AQOAT® (HPMCAS): ammonia-neutralized method - part 3: stability of the coated preparations [A-013]
    Aqueous fine particle coating with angled spray [A-044]
    Aqueous formulation of Shin-Etsu AQOAT® (HPMCAS) containing an amino acid as stabilizer - comparison of formulation and process parameters on different coating equipment [A-055]
    Comparative study of various coating methods with Shin-Etsu AQOAT® (HPMCAS) for pellets [A-060]
    Comparison of mini-tablets enteric coating with Shin-Etsu AQOAT® (HPMCAS) using perforated pan or fluid bed coating equipment [A-056]
    Concentration - viscosity curve of Shin-Etsu AQOAT® (HPMCAS) [A-064]
    Direct compression of spray dried dispersion [A-072]
    Dissolution behavior of coated fine particles by aqueous and solvent coating [A-045, H-013]
    Effect of hot melt extrusion on the physicochemical properties of Shin-Etsu AQOAT® (HPMCAS) [A-017]
    Effect of substitution of Shin-Etsu AQOAT® (HPMCAS) on dissolution profile of nifedipine solid dispersions (SD) prepared by Hot Melt Extrusion [A-032]
    Enteric coating of hard gelatin capsules using Shin-Etsu AQOAT® (HPMCAS) [A-029]
    Enteric coating of omeprazol granules using Shin-Etsu AQOAT® (HPMCAS) [A-031]
    Enteric coating with Shin-Etsu AQOAT® (HPMCAS) by using water-ethanol solution [A-004]
    Examples of aqueous dispersion coating using Shin-Etsu AQOAT® (HPMCAS) [A-003]
    Impact of process parameters to solid dispersion particles [A-071]
    Influence of alcohol on gastric resistance of Shin-Etsu AQOAT® (HPMCAS) [A-014]
    IR spectrums of HPMCP and Shin-Etsu AQOAT® [H-017, A-054]
    Mechanical properties of hot melt extruded amorphous solid dispersion with Shin-Etsu AQOAT® (HPMCAS) [A-073]
    Milling and downstream processing of hot melt extruded (HME) amorphous solid dispersion with Shin-Etsu AQOAT® (HPMCAS) [A-067]
    Minimum film formation temperature of Shin-Etsu AQOAT® (HPMCAS) (2) [A-047]
    Minimum film formation temperature of Shin-Etsu AQOAT® (HPMCAS) [A-005]
    Molecular weight of Shin-Etsu AQOAT® (HPMCAS) [A-007]
    Nifedipine solid dispersion using Shin-Etsu AQOAT® - preparation by HME and downstream processing [A-051]
    Partially neutralized coating technique using Shin-Etsu AQOAT® (HPMCAS) [A-037]
    Scale-up of tablet enteric coating using the partially ammonia neutralized Shin-Etsu AQOAT® (HPMCAS) dispersion [A-068]
    Solid dispersions (SD) using Shin-Etsu AQOAT® (HPMCAS) by holt melt extrusion [A-018]
    Solubility of Shin-Etsu AQOAT® (HPMCAS) in alkali solutions for cleaning media after coating operations [A-021]
    Solubility of Shin-Etsu AQOAT® (HPMCAS) in mixed organic solvents [A-035]
    Solution preparation of HPMCP and Shin-Etsu AQOAT® (HPMCAS) [H-019, A-058]
    Stability of Shin-Etsu AQOAT® (HPMCAS) at high temperatures [A-010]
    Taste masking coating for quinine tablets [A-061]
    Taste masking coating using Shin-Etsu AQOAT® (HPMCAS) and PHARMACOAT® with controlled release [A-063, P-018]
    Triacetin as an alternative plasticizer for aqueous dispersion with Shin-Etsu AQOAT® (HPMCAS) [A-057]
    Shin-Etsu AQOAT® AS-HG HPMCAS, 1000 µm, opening pH>6.5NF, JPJapan Very suitable Select
    Related documentsLanguagesAvailable as Download or Request
    Brochures
    Guide to Applications
    Pharmaceutical Excipients
    Shin-Etsu AQOAT®
    Safety Data Sheets
    Safety Data Sheet
    Technical Information
    3D printing tablets with Shin-Etsu AQOAT® (HPMCAS) [A-069]
    Application of Shin-Etsu AQOAT® (HPMCAS) as a carrier in solid dispersion [A-028]
    Application of Shin-Etsu AQOAT® (HPMCAS) in extended release (ER) matrix tablet formulation [A-070]
    Aqueous based enteric formulation of Shin-Etsu AQOAT® (HPMCAS) containing amino acid as a stabilizer [A-049]
    Aqueous dispersion coating using Shin-Etsu AQOAT® (HPMCAS) (Coating parameters of a tablet batch size 5-100kg) [A-002]
    Aqueous dispersion coating using Shin-Etsu AQOAT® (HPMCAS) (Preparation of coating dispersion) [A-001]
    Aqueous dispersion coating using Shin-Etsu AQOAT® (HPMCAS) (Using a small tabletop coating machine we coated tablet batch size of 300g) [A-006]
    Aqueous enteric coating for lansoprazole using Shin-Etsu AQOAT® (HPMCAS) [A-059]
    Aqueous enteric coating for soft gelatin capsule using Shin-Etsu AQOAT® (HPMCAS) [A-043]
    Aqueous enteric coating for soft gelatin capsule with Shin-Etsu AQOAT® (HPMCAS) [A-062]
    Aqueous enteric coating using Shin-Etsu AQOAT® (HPMCAS) for Mini-Tablets [A-053]
    Aqueous enteric coating with Shin-Etsu AQOAT® (HPMCAS): ammonia-neutralized method - part 1: solution and film properties [A-008]
    Aqueous enteric coating with Shin-Etsu AQOAT® (HPMCAS): ammonia-neutralized method - part 2: examples of coating applications [A-012]
    Aqueous enteric coating with Shin-Etsu AQOAT® (HPMCAS): ammonia-neutralized method - part 3: stability of the coated preparations [A-013]
    Aqueous fine particle coating with angled spray [A-044]
    Aqueous formulation of Shin-Etsu AQOAT® (HPMCAS) containing an amino acid as stabilizer - comparison of formulation and process parameters on different coating equipment [A-055]
    Comparative study of various coating methods with Shin-Etsu AQOAT® (HPMCAS) for pellets [A-060]
    Comparison of mini-tablets enteric coating with Shin-Etsu AQOAT® (HPMCAS) using perforated pan or fluid bed coating equipment [A-056]
    Concentration - viscosity curve of Shin-Etsu AQOAT® (HPMCAS) [A-064]
    Direct compression of spray dried dispersion [A-072]
    Dissolution behavior of coated fine particles by aqueous and solvent coating [A-045, H-013]
    Effect of hot melt extrusion on the physicochemical properties of Shin-Etsu AQOAT® (HPMCAS) [A-017]
    Effect of substitution of Shin-Etsu AQOAT® (HPMCAS) on dissolution profile of nifedipine solid dispersions (SD) prepared by Hot Melt Extrusion [A-032]
    Enteric coating of hard gelatin capsules using Shin-Etsu AQOAT® (HPMCAS) [A-029]
    Enteric coating of omeprazol granules using Shin-Etsu AQOAT® (HPMCAS) [A-031]
    Enteric coating with Shin-Etsu AQOAT® (HPMCAS) by using water-ethanol solution [A-004]
    Examples of aqueous dispersion coating using Shin-Etsu AQOAT® (HPMCAS) [A-003]
    Impact of process parameters to solid dispersion particles [A-071]
    Influence of alcohol on gastric resistance of Shin-Etsu AQOAT® (HPMCAS) [A-014]
    IR spectrums of HPMCP and Shin-Etsu AQOAT® [H-017, A-054]
    Mechanical properties of hot melt extruded amorphous solid dispersion with Shin-Etsu AQOAT® (HPMCAS) [A-073]
    Milling and downstream processing of hot melt extruded (HME) amorphous solid dispersion with Shin-Etsu AQOAT® (HPMCAS) [A-067]
    Minimum film formation temperature of Shin-Etsu AQOAT® (HPMCAS) (2) [A-047]
    Minimum film formation temperature of Shin-Etsu AQOAT® (HPMCAS) [A-005]
    Molecular weight of Shin-Etsu AQOAT® (HPMCAS) [A-007]
    Nifedipine solid dispersion using Shin-Etsu AQOAT® - preparation by HME and downstream processing [A-051]
    Partially neutralized coating technique using Shin-Etsu AQOAT® (HPMCAS) [A-037]
    Scale-up of tablet enteric coating using the partially ammonia neutralized Shin-Etsu AQOAT® (HPMCAS) dispersion [A-068]
    Solid dispersions (SD) using Shin-Etsu AQOAT® (HPMCAS) by holt melt extrusion [A-018]
    Solubility of Shin-Etsu AQOAT® (HPMCAS) in alkali solutions for cleaning media after coating operations [A-021]
    Solubility of Shin-Etsu AQOAT® (HPMCAS) in mixed organic solvents [A-035]
    Solution preparation of HPMCP and Shin-Etsu AQOAT® (HPMCAS) [H-019, A-058]
    Stability of Shin-Etsu AQOAT® (HPMCAS) at high temperatures [A-010]
    Taste masking coating for quinine tablets [A-061]
    Taste masking coating using Shin-Etsu AQOAT® (HPMCAS) and PHARMACOAT® with controlled release [A-063, P-018]
    Triacetin as an alternative plasticizer for aqueous dispersion with Shin-Etsu AQOAT® (HPMCAS) [A-057]
    TYLOPUR® 603 Hypromellose 2910, 3 mPasUSP, EP, JP, EXCiPACTGermany Very suitable Select
    Related documentsLanguagesAvailable as Download or Request
    Brochures
    Guide to Applications
    Pharmaceutical Excipients
    TYLOPUR®
    Safety Data Sheets
    Tylopur 603
    TYLOPUR® 645 Hypromellose 2910, 4.5 mPasUSP, EP, JP, EXCiPACTGermany Very suitable Select
    Related documentsLanguagesAvailable as Download or Request
    Brochures
    Guide to Applications
    Pharmaceutical Excipients
    TYLOPUR®
    Safety Data Sheets
    Tylopur 645
    TYLOPUR® 605 Hypromellose 2910, 5 mPasUSP, EP, JP, EXCiPACTGermany Suitable Select
    Related documentsLanguagesAvailable as Download or Request
    Brochures
    Guide to Applications
    Pharmaceutical Excipients
    TYLOPUR®
    Safety Data Sheets
    Tylopur 605
    TYLOPUR® 606 Hypromellose 2910, 6 mPasUSP, EP, JP, EXCiPACTGermany Suitable Select
    Related documentsLanguagesAvailable as Download or Request
    Brochures
    Guide to Applications
    Pharmaceutical Excipients
    TYLOPUR®
    Safety Data Sheets
    Tylopur 606

    Leading polymers for amorphous solid dispersion

    • Shin-Etsu AQOAT® HPMCAS
    • PHARMACOAT® and TYLOPUR® low viscosity hypromellose
    • HPMCP

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