Healthcare

Tablets and Pellets

The most frequently used oral solid dosage forms.

Tablets and Pellets

Tablets and pellets are the most common oral solid dosage forms. Tablets are cost effectively prepared by compression processes. Pellets are further processed by filling into capsules. Tablets are a flexible dosage form as immediate release and extended release tablets are available just by changing the excipients. Both, tablets and pellets may be coated for further functionalization. For example to increase swallow-ability or provide an enteric protection. Shin-Etsu provides excipients to prepare

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    Tablet Coating

    Film coatings of this type are now in widespread use throughout the world. Although drug properties are the key factor in medicinal formulations, the physical form or the finish of a preparation is also important. PHARMACOAT® and TYLOPUR® hypromellose are easy to use as a film coating material and give an excellent finish. It is very versatile, and is suitable for many applications in the design of film-coated tablet formulations. PHARMACOAT® and TYLOPUR® films have the tough and flexible characteristics of cellulose derivatives. Although hypromellose film is not brittle, as acrylic polymer is, addition of a plasticizer such as polyethylene glycol (PEG 6000) is effective when highly flexible film is required. When PHARMACOAT® and TYLOPUR® films are used for film coating, sometimes titanium dioxide or pigments, as well as talc can be added to provide a smooth and colorful film.

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    An organic coating method with Pharmacoat, with mixed solvent of high content of ethanol and water
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    Growth of microorganisms in aqueous solution of Pharmacoat
    Stability of Pharmacoat solution in sterilization
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    PHARMACOAT® 606 Hypromellose 2910, 6 mPasUSP, EP, JPJapan Very suitable Select
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    An organic coating method with Pharmacoat, with mixed solvent of high content of ethanol and water
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    Growth of microorganisms in aqueous solution of Pharmacoat
    Stability of Pharmacoat solution in sterilization
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    Pellet Coating

    Pellets coating prevents chemical interaction of API and excipients and improves the pellet surface. However regular aqueous film coating agents are of sticky nature and the low weight of pellets might lead to agglomeration during the fluid bed coating process. METOLOSE® SM-4, an extremely low viscosity methyl cellulose is useful for aqueous film coating of pellets since it is less sticky and water soluble.

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    Taste Masking

    Taste making of bitter tasting drugs is a common issue in formulation development. Taste masking of fine granules is sometime a major challenge due to the delay in drug release and difficulty of the coating operation. You can use an aqueous coating using METOLOSE® SM-4 without a sticking problem and no delay of dissolution. If you require time release of API after lag time for 5-10 minutes after administration is a feature of the dissolution behavior of sugar coating and such coating is a suitable method for taste masking. Combination of PHARMACOAT® and enteric coating material, such as Shin-Etsu AQOAT® can also be coated on a tablet for taste masking effect.

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    Enteric/delayed release coating (solvent)

    An enteric coating agent is used to protect drugs from degradation by gastric acid or to protect gastric mucosa from irritating drugs. Thus, an enteric coating agent is insoluble in gastric juice, and it immediately dissolves when the enteric preparation transfers to the small intestine. HPMCP (hypromellose phthalate) and Shin-Etsu AQOAT® (hypromellose acetate succinate) were introduced into the market as an alternative for enteric coating.

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    Enteric/delayed release coating (aqueous suspension & dry)

    Shin-Etsu AQOAT® is a enteric polymer suitable for aqueous polymer coatings. The coating dispersion is prepared with the HPMCAS-“F” fine powder grades to ensure trouble-free rapid coating process. "Dry coating" is a unique technique in which the polymer powder is directly applied to tablets or granules and the powder layer coalesces to form a film quickly by curing. In 2000, a Japanese pharmaceutical company commercialized this technique using Shin-Etsu AQOAT® for the first time. This technique is applicable for both tablets and granules using a regular apparatus with a powder feeding system. Ask your sales representative for further information.

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    Molecular Weight of Shin-Etsu Aqoat (HPMCAS)

    Enteric/delayed release coating (aqueous solution)

    When Shin-Etsu AQOAT® is fully neutralized (e.g. by ammonia), it dissolves completely in the coating media. In this case the “G” granular grades are applied and no surfactant for wetting of the HPMCAS is required, simplifying your formulation.

    Recommended products

    GradesDescriptionPharmacopoeiaOriginRecommendationKnowledge Base
    Shin-Etsu AQOAT® AS-LG HPMCAS, 1000 µm, opening pH>5.5NF, JPJapan Very suitable Select
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    Brochures
    Guide to Applications
    Pharmaceutical Excipients
    Shin-Etsu AQOAT®
    Safety Data Sheets
    Safety Data Sheet
    Technical Information
    Aqueous Dispersion Coating Using Shin-Etsu Aqoat
    Aqueous Dispersion Coating Using Shin-Etsu Aqoat
    Aqueous Dispersion Coating Using Shin-Etsu Aqoat
    Enteric Coating with Shin-Etsu Aqoat (HPMCAS) by Using Water-Ethanol Solution
    Examples of Aqueous Dispersion Coating Using Shin-Etsu Aqoat
    Minimum Film Formation Temperature of Shin-Etsu Aqoat
    Molecular Weight of Shin-Etsu Aqoat (HPMCAS)
    Shin-Etsu AQOAT® AS-MG HPMCAS, 1000 µm, opening pH>6.0NF, JPJapan Very suitable Select
    Related documentsLanguagesAvailable as Download or Request
    Brochures
    Guide to Applications
    Pharmaceutical Excipients
    Shin-Etsu AQOAT®
    Safety Data Sheets
    Safety Data Sheet
    Technical Information
    Aqueous Dispersion Coating Using Shin-Etsu Aqoat
    Aqueous Dispersion Coating Using Shin-Etsu Aqoat
    Aqueous Dispersion Coating Using Shin-Etsu Aqoat
    Enteric Coating with Shin-Etsu Aqoat (HPMCAS) by Using Water-Ethanol Solution
    Examples of Aqueous Dispersion Coating Using Shin-Etsu Aqoat
    Minimum Film Formation Temperature of Shin-Etsu Aqoat
    Molecular Weight of Shin-Etsu Aqoat (HPMCAS)
    Shin-Etsu AQOAT® AS-HG HPMCAS, 1000 µm, opening pH>6.5NF, JPJapan Very suitable Select
    Related documentsLanguagesAvailable as Download or Request
    Brochures
    Guide to Applications
    Pharmaceutical Excipients
    Shin-Etsu AQOAT®
    Safety Data Sheets
    Safety Data Sheet
    Technical Information
    Aqueous Dispersion Coating Using Shin-Etsu Aqoat
    Aqueous Dispersion Coating Using Shin-Etsu Aqoat
    Aqueous Dispersion Coating Using Shin-Etsu Aqoat
    Enteric Coating with Shin-Etsu Aqoat (HPMCAS) by Using Water-Ethanol Solution
    Examples of Aqueous Dispersion Coating Using Shin-Etsu Aqoat
    Minimum Film Formation Temperature of Shin-Etsu Aqoat
    Molecular Weight of Shin-Etsu Aqoat (HPMCAS)

    Sugar coating binder

    PHARMACOAT® SB-4 is a hypromellose grade used as a binder for sugar coating instead of gelatin and gum arabic.

    Recommended products

    GradesDescriptionPharmacopoeiaOriginRecommendationKnowledge Base
    METOLOSE® SB-4 Hypromellose 2208, 4 mPasUSP, EP, JPJapan Very suitable Select
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    Brochures
    Guide to Applications
    METOLOSE®
    Pharmaceutical Excipients
    Safety Data Sheets
    Safety Data Sheet
    Technical Information
    Adjusting viscosity by blending two grades of Metolose
    Solubility of HPMC and MC in organic solvents
    Taste masking for fine granules by Metolose and an acrylic polymer

    Sustained release (matrix tablets)

    Hydrophilic matrix systems designed with water-soluble polymers, such as hypromellose, were first introduced in the early 1970s. Hydrophilic matrix system have allowed more controllable and reproducible drug release by controlling the chemical and physical properties of the polymer. METOLOSE® SR and TYLOPUR® SR (hypromellose) is especially suitable for this application, and provides a genuine consistency in the final products.

    Recommended products

    GradesDescriptionPharmacopoeiaOriginRecommendationKnowledge Base
    METOLOSE® 60SH´s Hypromellose 2910, different viscosities 50-10000 mPasUSP, EP, JPJapan Suitable Select
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    Guide to Applications
    METOLOSE®
    Pharmaceutical Excipients
    Safety Data Sheets
    Safety Data Sheet
    Technical Information
    Adjusting viscosity by blending two grades of Metolose
    Solubility of HPMC and MC in organic solvents
    Taste masking for fine granules by Metolose and an acrylic polymer
    METOLOSE® 65SH´s Hypromellose 2906, different viscosities 50-4000 mPasUSP, EP, JPJapan Suitable Select
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    Guide to Applications
    METOLOSE®
    Pharmaceutical Excipients
    Safety Data Sheets
    Safety Data Sheet
    Technical Information
    Adjusting viscosity by blending two grades of Metolose
    Solubility of HPMC and MC in organic solvents
    Taste masking for fine granules by Metolose and an acrylic polymer
    METOLOSE® 90SH´s Hypromellose 2208, different viscosities 4000-100000 mPasUSP, EP, JPJapan Suitable Select
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    METOLOSE®
    Pharmaceutical Excipients
    Safety Data Sheets
    Safety Data Sheet
    Technical Information
    Adjusting viscosity by blending two grades of Metolose
    Solubility of HPMC and MC in organic solvents
    Taste masking for fine granules by Metolose and an acrylic polymer
    METOLOSE® SR 90SH-100SR Hypromellose 2208, 100 mPas, sustained releaseUSP, EP, JPJapan Very suitable Select
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    METOLOSE SR®
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    Safety Data Sheets
    Safety Data Sheet
    Technical Information
    A study on the robustness of the wet granulation process to prepare Metformin HCL extended-release matrix tablet using Metolose 90SH-15000SR
    Bilayer tablets using L-HPC and Metolose SR
    Comparison between direct compression and wet granulation in hydrophilic matrix tablet using Metolose SR
    Formulation Example: Lithium Carbonate Extended-Release tablet using Metolose SR
    Solvent selection in wet granulation for hydrophilic matrix tablets using Metolose SR
    Sustained release of Naproxen using Metolose SR
    METOLOSE® SR 90SH-4000SR Hypromellose 2208, 4000 mPas, sustained releaseUSP, EP, JPJapan Very suitable Select
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    METOLOSE SR®
    Pharmaceutical Excipients
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    Technical Information
    A study on the robustness of the wet granulation process to prepare Metformin HCL extended-release matrix tablet using Metolose 90SH-15000SR
    Bilayer tablets using L-HPC and Metolose SR
    Comparison between direct compression and wet granulation in hydrophilic matrix tablet using Metolose SR
    Formulation Example: Lithium Carbonate Extended-Release tablet using Metolose SR
    Solvent selection in wet granulation for hydrophilic matrix tablets using Metolose SR
    Sustained release of Naproxen using Metolose SR
    METOLOSE® SR 90SH-15000SR Hypromellose 2208, 15000 mPas, sustained releaseUSP, EP, JPJapan Very suitable Select
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    METOLOSE SR®
    Pharmaceutical Excipients
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    A study on the robustness of the wet granulation process to prepare Metformin HCL extended-release matrix tablet using Metolose 90SH-15000SR
    Bilayer tablets using L-HPC and Metolose SR
    Comparison between direct compression and wet granulation in hydrophilic matrix tablet using Metolose SR
    Formulation Example: Lithium Carbonate Extended-Release tablet using Metolose SR
    Solvent selection in wet granulation for hydrophilic matrix tablets using Metolose SR
    Sustained release of Naproxen using Metolose SR
    METOLOSE® SR 90SH-100000SR Hypromellose 2208, 100000 mPas, sustained releaseUSP, EP, JPJapan Very suitable Select
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    METOLOSE SR®
    Pharmaceutical Excipients
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    Safety Data Sheet
    Technical Information
    A study on the robustness of the wet granulation process to prepare Metformin HCL extended-release matrix tablet using Metolose 90SH-15000SR
    Bilayer tablets using L-HPC and Metolose SR
    Comparison between direct compression and wet granulation in hydrophilic matrix tablet using Metolose SR
    Formulation Example: Lithium Carbonate Extended-Release tablet using Metolose SR
    Solvent selection in wet granulation for hydrophilic matrix tablets using Metolose SR
    Sustained release of Naproxen using Metolose SR
    TYLOPUR® 60SH-50 Hypromellose 2910, 50 mPasUSP, EP, JPGermany Suitable Select
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    Brochures
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    Pharmaceutical Excipients
    Tylopur®
    Safety Data Sheets
    Tylopur 60SH-50
    TYLOPUR® 60SH-4000 Hypromellose 2910, 4000 mPasUSP, EP, JPGermany Suitable Select
    Related documentsLanguagesAvailable as Download or Request
    Safety Data Sheets
    Tylopur 60SH-4000
    TYLOPUR® SR 90SH-100SR Hypromellose 2208, 100 mPas, sustained releaseUSP, EP, JPGermany Very suitable Select
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    Tylopur 90SH-100SR
    TYLOPUR® 60SH-13000 Hypromellose 2910, 13000 mPasUSP, EP, JPGermany Suitable Select
    Related documentsLanguagesAvailable as Download or Request
    Safety Data Sheets
    Tylopur 60SH-10000
    TYLOPUR® SR 90SH-4000SR Hypromellose 2208, 4000 mPas, sustained releaseUSP, EP, JPGermany Very suitable Select
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    Brochures
    Guide to Applications
    Pharmaceutical Excipients
    Safety Data Sheets
    Tylopur 90SH-4000SR
    TYLOPUR® SR 90SH-15000SR Hypromellose 2208, 15000 mPas, sustained releaseUSP, EP, JPGermany Very suitable Select
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    Tylopur 90SH-15000SR
    TYLOPUR® SR 90SH-100000SR Hypromellose 2208, 100000 mPas, sustained releaseUSP, EP, JPGermany Very suitable Select
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    Tylopur 90SH-100000SR

    Binder solution (WG)

    PHARMACOAT®, METOLOSE® and TYLOPUR® can also be used as a binder for granulation. The fine particle size (average 50-70 μm) allows good mixture with the vehicle (lactose/cornstarch) and PHARMACOAT®, METOLOSE® and TYLOPUR® are effective for fluidized bed granulation and high shear mixer granulation (dry-blend).

    Recommended products

    GradesDescriptionPharmacopoeiaOriginRecommendationKnowledge Base
    PHARMACOAT® 603 Hypromellose 2910, 3 mPasUSP, EP, JPJapan Very suitable Select
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    Guide to Applications
    Pharmaceutical Excipients
    PHARMACOAT®
    Safety Data Sheets
    Safety Data Sheet
    Technical Information
    An organic coating method with Pharmacoat, with mixed solvent of high content of ethanol and water
    Application of Pharmacoat as a carrier in solid dispersion
    Colour coating with Pharmacoat
    Effect of moisture content on the mechanical properties of cast HPMC films
    Effect of plasticizers and other additives on the mechanical properties of cast hypromellose films
    Filtration of Pharmacoat solutions
    Growth of microorganisms in aqueous solution of Pharmacoat
    Stability of Pharmacoat solution in sterilization
    Timed-release coating with Pharmacoat and Shin-Etsu AQOAT® for taste-masking effect
    PHARMACOAT® 645 Hypromellose 2910, 4.5 mPasUSP, EP, JPJapan Suitable Select
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    Brochures
    Guide to Applications
    Pharmaceutical Excipients
    PHARMACOAT®
    Safety Data Sheets
    Safety Data Sheet
    Technical Information
    An organic coating method with Pharmacoat, with mixed solvent of high content of ethanol and water
    Application of Pharmacoat as a carrier in solid dispersion
    Colour coating with Pharmacoat
    Effect of moisture content on the mechanical properties of cast HPMC films
    Effect of plasticizers and other additives on the mechanical properties of cast hypromellose films
    Filtration of Pharmacoat solutions
    Growth of microorganisms in aqueous solution of Pharmacoat
    Stability of Pharmacoat solution in sterilization
    Timed-release coating with Pharmacoat and Shin-Etsu AQOAT® for taste-masking effect
    PHARMACOAT® 606 Hypromellose 2910, 6 mPasUSP, EP, JPJapan Suitable Select
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    Brochures
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    Pharmaceutical Excipients
    PHARMACOAT®
    Safety Data Sheets
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    Technical Information
    An organic coating method with Pharmacoat, with mixed solvent of high content of ethanol and water
    Application of Pharmacoat as a carrier in solid dispersion
    Colour coating with Pharmacoat
    Effect of moisture content on the mechanical properties of cast HPMC films
    Effect of plasticizers and other additives on the mechanical properties of cast hypromellose films
    Filtration of Pharmacoat solutions
    Growth of microorganisms in aqueous solution of Pharmacoat
    Solubility of Pharmacoat 606 in alcohol-water mixtures
    Stability of Pharmacoat solution in sterilization
    Timed-release coating with Pharmacoat and Shin-Etsu AQOAT® for taste-masking effect
    METOLOSE® SM-4 Methyl cellulose, 4 mPasUSP, EP, JPJapan Very suitable Select
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    Brochures
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    METOLOSE®
    Pharmaceutical Excipients
    Safety Data Sheets
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    Technical Information
    Adjusting viscosity by blending two grades of Metolose
    Metolose SM-4 for pellet film coating
    Solubility of HPMC and MC in organic solvents
    Taste masking for fine granules by Metolose and an acrylic polymer
    TYLOPUR® 603 Hypromellose 2910, 3 mPasUSP, EP, JPGermany Very suitable Select
    Related documentsLanguagesAvailable as Download or Request
    Brochures
    Guide to Applications
    Pharmaceutical Excipients
    Tylopur®
    Safety Data Sheets
    Tylopur 603
    TYLOPUR® 645 Hypromellose 2910, 4.5 mPasUSP, EP, JPGermany Suitable Select
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    Tylopur®
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    Tylopur 645
    TYLOPUR® 605 Hypromellose 2910, 5 mPasUSP, EP, JPGermany Suitable Select
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    Safety Data Sheets
    Tylopur 605
    TYLOPUR® 606 Hypromellose 2910, 6 mPasUSP, EP, JPGermany Suitable Select
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    Anti-capping

    One of the benefits of L-HPC is to resolve “capping” in immediate release formulations, which is a typical problem in the tableting process. Several reports have highlighted that capping is caused by a high residual die-wall pressure during the tableting process. L-HPC reduces the residual die-wall force and ejection force during the tableting process. For this application we recommend that you use LH-11. However using LH-21, 22 or NBD-020 also acceptable results when better flow is required.

    Recommended products

    GradesDescriptionPharmacopoeiaOriginRecommendationKnowledge Base
    L-HPC LH-11 50 µm, 11 % HPONF, EP, JPJapan Very suitable Select
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    Safety Data Sheet
    L-HPC LH-21. 22 45 µm, 8-11 % HPONF, EP, JPJapan Suitable Select
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    L-HPC
    Pharmaceutical Excipients
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    L-HPC NBD-020 45 µm, 14 % HPONF, EP, JPJapan Suitable Select
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    Pharmaceutical Excipients
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    Dissolution improvement for WG

    To accelerate API dissolution from immediate release tablets, a quick disintegration into fine particles by fast and strong swelling is preferred. LH-B1 featuring highest swelling rate and pressure among the L-HPC grades gives you the best result.

    Recommended products

    GradesDescriptionPharmacopoeiaOriginRecommendationKnowledge Base
    L-HPC LH-21. 22 45 µm, 8-11 % HPONF, EP, JPJapan Suitable Select
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    Pharmaceutical Excipients
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    L-HPC LH-B1 50 µm, 11 % HPONF, EP, JPJapan Very suitable Select
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    Pharmaceutical Excipients
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    Safety Data Sheet

    Disintegration improvement for WG

    All L-HPC grades give a fast disintegration of immediate release tablets. However there are differences in swelling rate and pressure. The L-HPC B1 grade with highest swelling rate and pressure gives you the quickest disintegration when a formulation is processed by WG and compressed into tablets

    Recommended products

    GradesDescriptionPharmacopoeiaOriginRecommendationKnowledge Base
    L-HPC LH-B1 50 µm, 11 % HPONF, EP, JPJapan Very suitable Select
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    L-HPC
    Pharmaceutical Excipients
    Safety Data Sheets
    Safety Data Sheet

    Binding for WG

    In wet granulation, L-HPC is beneficial in the powder blend to increase binding and compactibility. Among the L-HPC grades, LH-11 and LH-21 are two recommendations for wet granulated immediate release formulations.

    Recommended products

    GradesDescriptionPharmacopoeiaOriginRecommendationKnowledge Base
    L-HPC LH-11 50 µm, 11 % HPONF, EP, JPJapan Very suitable Select
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    Pharmaceutical Excipients
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    L-HPC LH-21. 22 45 µm, 8-11 % HPONF, EP, JPJapan Suitable Select
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    L-HPC
    Pharmaceutical Excipients
    Safety Data Sheets
    Safety Data Sheet
    L-HPC LH-31. 32 20 µm, 8-11 % HPONF, EP, JPJapan Suitable Select
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    L-HPC
    Pharmaceutical Excipients
    Safety Data Sheets
    Safety Data Sheet
    L-HPC NBD-020 45 µm, 14 % HPONF, EP, JPJapan Very suitable Select
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    Pharmaceutical Excipients
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    L-HPC NBD-021 45 µm, 11 % HPONF, EP, JPJapan Suitable Select
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    Pharmaceutical Excipients
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    L-HPC NBD-022 45 µm, 8 % HPONF, EP, JPJapan Suitable Select
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    Disintegration improvement for DC

    Powder flow and compressibility are key in direct compression. For immediate release direct compressed mixtures, the L-HPC Grades LH-B1, and NBD grades 021, and 022 are recommended.

    Recommended products

    GradesDescriptionPharmacopoeiaOriginRecommendationKnowledge Base
    L-HPC LH-B1 50 µm, 11 % HPONF, EP, JPJapan Suitable Select
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    L-HPC NBD-021 45 µm, 11 % HPONF, EP, JPJapan Suitable Select
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    L-HPC NBD-022 45 µm, 8 % HPONF, EP, JPJapan Very suitable Select
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    Binding for RC

    Roller compaction is a dry granulation technique. The powder blend requires sufficient binding to form a stable ribbon and larger granules with less fine powders after the milling step. L-HPC NBD-grades are low-substituted hydroxypropyl cellulose and increase the binding properties of your roller compaction formulation. At the same time L-HPC acts as disintegrant ensuring the quick disintegration of your roller compacted IR formulation. Best performance in roller compaction give the compactibility optimized L-HPC NBD grades. LH-31/32 is suitable as well.

    Recommended products

    GradesDescriptionPharmacopoeiaOriginRecommendationKnowledge Base
    L-HPC LH-31. 32 20 µm, 8-11 % HPONF, EP, JPJapan Suitable Select
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    L-HPC NBD-020 45 µm, 14 % HPONF, EP, JPJapan Very suitable Select
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    L-HPC NBD-021 45 µm, 11 % HPONF, EP, JPJapan Very suitable Select
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    L-HPC NBD-022 45 µm, 8 % HPONF, EP, JPJapan Very suitable Select
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    Dissolution improvement from drug layer

    L-HPC enhances dissolution from a coated drug layer by its swelling properties. L-HPC 31 and 32 can also be used in powder layering the API, this can be carried out in a centrifugal coater using a PHARMACOAT® / TYLOPUR® binder solution.

    Recommended products

    GradesDescriptionPharmacopoeiaOriginRecommendationKnowledge Base
    L-HPC LH-31. 32 20 µm, 8-11 % HPONF, EP, JPJapan Suitable Select
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    L-HPC NBD-020 45 µm, 14 % HPONF, EP, JPJapan Very suitable Select
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    Pellet Extrusion

    As well as tableting, L-HPC is also applicable for pellet extrusion. Micronized grades (typically LH-31) are best suited for this application because smaller particles can easily pass through the screen. L-HPC provides wet mass with a “buffer effect” where the wet mass accepts a wider range of water content. L-HPC plasticizes wet mass and shows greater productivity (extrusion speed and yield). The final pellets show quick disintegration and better friability compared with non-L-HPC formulations.

    Recommended products

    GradesDescriptionPharmacopoeiaOriginRecommendationKnowledge Base
    L-HPC LH-21. 22 45 µm, 8-11 % HPONF, EP, JPJapan Suitable Select
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    L-HPC LH-31. 32 20 µm, 8-11 % HPONF, EP, JPJapan Very suitable Select
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    Oral Dispersible Tablets (ODT)

    Orally disintegrating tablets (ODT) differ from traditional tablets in that they are designed to be dissolved in the oral cavity rather than swallowed whole. Shin-Etsu developed a co-processed excipient especially for the ODT application by direct compression. This excipient is named SmartEx®. NBD-022 is our second recommended product for this application as it has the quickest disintegration and a better feeling in the mouth than the other NBD grades.

    Recommended products

    GradesDescriptionPharmacopoeiaOriginRecommendationKnowledge Base
    L-HPC LH-31. 32 20 µm, 8-11 % HPONF, EP, JPJapan Suitable Select
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    L-HPC NBD-020 45 µm, 14 % HPONF, EP, JPJapan Suitable Select
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    L-HPC NBD-021 45 µm, 11 % HPONF, EP, JPJapan Suitable Select
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    L-HPC NBD-022 45 µm, 8 % HPONF, EP, JPJapan Very suitable Select
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    SmartEx® QD-50 Co-processed excipient, 50 µmJPEJapan Very suitable Select
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    SmartEx® QD-100 Co-processed excipient, 100 µmJPEJapan Very suitable Select
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    Pharmaceutical Excipients

    Shin-Etsu’s commitment

    • High quality and high batch to batch consistency of our excipients
    • Long established manufacturer of pharmaceutical excipients
    • Production in Japan and Germany

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