Healthcare

Shin-Etsu AQOAT®

Enteric coating polymer and solid dispersion carrier invented by Shin-Etsu in the 1980s

Shin-Etsu AQOAT®
Hypromellose acetate succinate is an enteric coating material

Hypromellose acetate succinate (HPMCAS, NF, JP) is an enteric coating material that can be used in aqueous or organic media.

Hypromellose is a non-toxic material which has been used in pharmaceutical, food, and cosmetic industries for many years. Based on hypromellose, acetyl and succinoyl groups are introduced to the hydroxyl groups of the backbone, and this constitutes Shin-Etsu AQOAT®, hypromellose acetate succinate (HPMCAS).

There are nine grades with different particle sizes (fine, medium, granular) and chemical substitution levels of acetyl and succinoyl groups to obtain an opening pH range from 5.5 to 6.5.

Shin-Etsu AQOAT® is the leading polymer in solid dispersion technology. It is suitable for spray-drying, hot melt extrusion, co-precipitation and other techniques. There are more than 14 approved products in the US using Shin-Etsu AQOAT® in solid dispersion.

Additionally, we designed our HME cleaner to support you with trouble free cleaning after the extrusion process. Please contact us for further information.

Shin-Etsu AQOAT® grades

GradesDescriptionRegulatoryOriginKnowledge Base
AS-LFHPMCAS, 5 µm, opening pH>5.5NF, JPJapan Select
Related documentsLanguagesAvailable as Download or Request
Brochures
Guide to Applications
Pharmaceutical Excipients
Shin-Etsu AQOAT®
Safety Data Sheets
Safety Data Sheet
Technical Information
Aqueous Dispersion Coating Using Shin-Etsu Aqoat
Aqueous Dispersion Coating Using Shin-Etsu Aqoat
Aqueous Dispersion Coating Using Shin-Etsu Aqoat
Enteric Coating with Shin-Etsu Aqoat (HPMCAS) by Using Water-Ethanol Solution
Examples of Aqueous Dispersion Coating Using Shin-Etsu Aqoat
Minimum Film Formation Temperature of Shin-Etsu Aqoat
Molecular Weight of Shin-Etsu Aqoat (HPMCAS)
AS-MFHPMCAS, 5 µm, opening pH>6.0NF, JPJapan Select
Related documentsLanguagesAvailable as Download or Request
Brochures
Guide to Applications
Pharmaceutical Excipients
Shin-Etsu AQOAT®
Safety Data Sheets
Safety Data Sheet
Technical Information
Aqueous Dispersion Coating Using Shin-Etsu Aqoat
Aqueous Dispersion Coating Using Shin-Etsu Aqoat
Aqueous Dispersion Coating Using Shin-Etsu Aqoat
Enteric Coating with Shin-Etsu Aqoat (HPMCAS) by Using Water-Ethanol Solution
Examples of Aqueous Dispersion Coating Using Shin-Etsu Aqoat
Minimum Film Formation Temperature of Shin-Etsu Aqoat
Molecular Weight of Shin-Etsu Aqoat (HPMCAS)
AS-HFHPMCAS, 5 µm, opening pH>6.5NF, JPJapan Select
Related documentsLanguagesAvailable as Download or Request
Brochures
Guide to Applications
Pharmaceutical Excipients
Shin-Etsu AQOAT®
Safety Data Sheets
Safety Data Sheet
Technical Information
Aqueous Dispersion Coating Using Shin-Etsu Aqoat
Aqueous Dispersion Coating Using Shin-Etsu Aqoat
Aqueous Dispersion Coating Using Shin-Etsu Aqoat
Enteric Coating with Shin-Etsu Aqoat (HPMCAS) by Using Water-Ethanol Solution
Examples of Aqueous Dispersion Coating Using Shin-Etsu Aqoat
Minimum Film Formation Temperature of Shin-Etsu Aqoat
Molecular Weight of Shin-Etsu Aqoat (HPMCAS)
AS-LMPHPMCAS, 200 µm, opening pH>5.5NF, JPJapan Select
Related documentsLanguagesAvailable as Download or Request
Brochures
Guide to Applications
Pharmaceutical Excipients
Shin-Etsu AQOAT®
Safety Data Sheets
Safety Data Sheet
Technical Information
Aqueous Dispersion Coating Using Shin-Etsu Aqoat
Aqueous Dispersion Coating Using Shin-Etsu Aqoat
Aqueous Dispersion Coating Using Shin-Etsu Aqoat
Enteric Coating with Shin-Etsu Aqoat (HPMCAS) by Using Water-Ethanol Solution
Examples of Aqueous Dispersion Coating Using Shin-Etsu Aqoat
Minimum Film Formation Temperature of Shin-Etsu Aqoat
Molecular Weight of Shin-Etsu Aqoat (HPMCAS)
AS-MMPHPMCAS, 200 µm, opening pH>6.0NF, JPJapan Select
Related documentsLanguagesAvailable as Download or Request
Brochures
Guide to Applications
Pharmaceutical Excipients
Shin-Etsu AQOAT®
Safety Data Sheets
Safety Data Sheet
Technical Information
Aqueous Dispersion Coating Using Shin-Etsu Aqoat
Aqueous Dispersion Coating Using Shin-Etsu Aqoat
Aqueous Dispersion Coating Using Shin-Etsu Aqoat
Enteric Coating with Shin-Etsu Aqoat (HPMCAS) by Using Water-Ethanol Solution
Examples of Aqueous Dispersion Coating Using Shin-Etsu Aqoat
Minimum Film Formation Temperature of Shin-Etsu Aqoat
Molecular Weight of Shin-Etsu Aqoat (HPMCAS)
AS-HMPHPMCAS, 200 µm, opening pH>6.5NF, JPJapan Select
Related documentsLanguagesAvailable as Download or Request
Brochures
Guide to Applications
Pharmaceutical Excipients
Shin-Etsu AQOAT®
Safety Data Sheets
Safety Data Sheet
Technical Information
Aqueous Dispersion Coating Using Shin-Etsu Aqoat
Aqueous Dispersion Coating Using Shin-Etsu Aqoat
Aqueous Dispersion Coating Using Shin-Etsu Aqoat
Enteric Coating with Shin-Etsu Aqoat (HPMCAS) by Using Water-Ethanol Solution
Examples of Aqueous Dispersion Coating Using Shin-Etsu Aqoat
Minimum Film Formation Temperature of Shin-Etsu Aqoat
Molecular Weight of Shin-Etsu Aqoat (HPMCAS)
AS-LGHPMCAS, 1000 µm, opening pH>5.5NF, JPJapan Select
Related documentsLanguagesAvailable as Download or Request
Brochures
Guide to Applications
Pharmaceutical Excipients
Shin-Etsu AQOAT®
Safety Data Sheets
Safety Data Sheet
Technical Information
Aqueous Dispersion Coating Using Shin-Etsu Aqoat
Aqueous Dispersion Coating Using Shin-Etsu Aqoat
Aqueous Dispersion Coating Using Shin-Etsu Aqoat
Enteric Coating with Shin-Etsu Aqoat (HPMCAS) by Using Water-Ethanol Solution
Examples of Aqueous Dispersion Coating Using Shin-Etsu Aqoat
Minimum Film Formation Temperature of Shin-Etsu Aqoat
Molecular Weight of Shin-Etsu Aqoat (HPMCAS)
AS-MGHPMCAS, 1000 µm, opening pH>6.0NF, JPJapan Select
Related documentsLanguagesAvailable as Download or Request
Brochures
Guide to Applications
Pharmaceutical Excipients
Shin-Etsu AQOAT®
Safety Data Sheets
Safety Data Sheet
Technical Information
Aqueous Dispersion Coating Using Shin-Etsu Aqoat
Aqueous Dispersion Coating Using Shin-Etsu Aqoat
Aqueous Dispersion Coating Using Shin-Etsu Aqoat
Enteric Coating with Shin-Etsu Aqoat (HPMCAS) by Using Water-Ethanol Solution
Examples of Aqueous Dispersion Coating Using Shin-Etsu Aqoat
Minimum Film Formation Temperature of Shin-Etsu Aqoat
Molecular Weight of Shin-Etsu Aqoat (HPMCAS)
AS-HGHPMCAS, 1000 µm, opening pH>6.5NF, JPJapan Select
Related documentsLanguagesAvailable as Download or Request
Brochures
Guide to Applications
Pharmaceutical Excipients
Shin-Etsu AQOAT®
Safety Data Sheets
Safety Data Sheet
Technical Information
Aqueous Dispersion Coating Using Shin-Etsu Aqoat
Aqueous Dispersion Coating Using Shin-Etsu Aqoat
Aqueous Dispersion Coating Using Shin-Etsu Aqoat
Enteric Coating with Shin-Etsu Aqoat (HPMCAS) by Using Water-Ethanol Solution
Examples of Aqueous Dispersion Coating Using Shin-Etsu Aqoat
Minimum Film Formation Temperature of Shin-Etsu Aqoat
Molecular Weight of Shin-Etsu Aqoat (HPMCAS)

Grades and applications

Application
 
Tablets & Pellets
Taste Masking
Enteric/delayed release coating (solvent)
Enteric/delayed release coating (aqueous suspension & dry)
Enteric/delayed release coating (aqueous solution)
Amorphous Solid Dispersion
Solvent free methods (HME)
solvent methods
Shin-Etsu AQOAT®
AS-LFAS-MFAS-HFAS-LMPAS-MMPAS-HMPAS-LGAS-MGAS-HG
                 
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• Suitable / •• Very Suitable

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