Technical Information

 

Healthcare Documents

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PHARMACOAT®
An organic coating method with Pharmacoat, with mixed solvent of high content of ethanol and water
Film coated tablets containing water sensitive API often use a coating solvent consisting of a high content of organic solvents such as ethanol in water. In this study, a method for solution preparation with Pharmacoat in mixed solvents of high ethanol content in water, and coating technique are introduced.
Application of Pharmacoat as a carrier in solid dispersion
Solid dispersion is a technique used to enhance the bioavailability of poorly-soluble drugs in increase their solubility. In this study, as solid dispersion preparation method using Pharmacoat as a carrier is introduced, along with its application to solid dosage forms.
Colour coating with Pharmacoat
Pharmacoat is widely used for film coating and this technical sheet includes typical colour coating formulations.
Effect of moisture content on the mechanical properties of cast HPMC films
The mechanical properties of coating films are important characteristics because they affect various properties of film-coated dosage forms.
Effect of plasticizers and other additives on the mechanical properties of cast hypromellose films
In this study, the effect of plasticizers, sugars and lower viscosity polymers on the mechanical properties of cast hypromellose films was investigated using various grades of Pharmacoat.
Filtration of Pharmacoat solutions
Filtration is a common technique to eliminate black specs. This technical sheet shows the filtration resistance of several formulations using Pharmacoat.
Growth of microorganisms in aqueous solution of Pharmacoat
Pharmacoat is widely used in film coating of solid dosage forms, were the adoption of the aqueous coating technique has become common place. In applying an aqueous film coating, it is necessary to control the microbiological content of the coating solution, especially when prepare in advance and allowed to stand for an extended period of time prior to use.
Solubility of Pharmacoat 606 in alcohol-water mixtures
The solubility of Pharmacoat 606 in the mixture of methanol/water, ethanol/water and isopropyl alcohol (IPA)/water was investigated.
Stability of Pharmacoat solution in sterilization
Heating is a common sterilization method for aqueous solution of Hypromellose. It has been recognized that 120 degree for 30 minutes is sufficient for the sterilization in most cases. This type of sterilization is typically used in the production of eye drops with polymer concentration below 1%.
Timed-release coating with Pharmacoat and Shin-Etsu AQOAT® for taste-masking effect
The time release of API after a lag time for 5-10 minutes after administration is a feature of the dissolution behavior of sugar coating, and such coating is a suitable method for taste masking.
METOLOSE®
Adjusting viscosity by blending two grades of Metolose
This technical sheet demonstrates how two different viscosity grades of Metolose can be blended together to obtain material with a desired viscosity.
Metolose SM-4 for pellet film coating
Film coating sometimes is used to protect coated pellets or to prevent chemical interactions between active ingredients and excipients, however regular film coating agents such as PHARMACOAT® are difficult to use for pellet coating due to agglomeration during the fluid bed coating process. METOLOSE® SM-4, an extremely low viscosity methycellulose is useful for aqueous film coating of pellets since it is less sticky and water soluble.
Solubility of HPMC and MC in organic solvents
Hypromellose and Methycellulose is insoluble in organic solvents and in this study shows the solubility of HPMC and MC is different organic solvents.  
Taste masking for fine granules by Metolose and an acrylic polymer
Taste masking is a common issue in formulation development. In this study, as aqueous coating using Metolose SM-4 and acrylic polymer was applied to taste masking.
METOLOSE® SR
A study on the robustness of the wet granulation process to prepare Metformin HCL extended-release matrix tablet using Metolose 90SH-15000SR
The robustness of the wet granulation process was investigated in preparing Metformin HCL extended release matrix tablets using Metolose 90SH 15000SR. To observe the relationship between the processing parameters and tablet performance, an orthogonal-array design was applied to the evaluation.  
Bilayer tablets using L-HPC and Metolose SR
The preparation of bilyaer tablets using L-HPC and Metolose SR was studied. The best grade of L-HPC was selected using preliminary study to reduce the anti lamination and then applied in a rotary tablet press.  
Comparison between direct compression and wet granulation in hydrophilic matrix tablet using Metolose SR
The purpose of this study was to compare direct compression and wet granulation for preparation of hydrophilic matrix tablets using Metolose SR. Tablet productivity using a s rotary tablet press was investigated, specifically for tablet weight deviation.
Formulation Example: Lithium Carbonate Extended-Release tablet using Metolose SR
Lithium Carbonate was incorporated into the formulation to demonstrate that Metolose SR can be used for an extended release.  
Solvent selection in wet granulation for hydrophilic matrix tablets using Metolose SR
An aqueous alcoholic solution is one of the suitable solvents to prepare hydrophilic matrix tablets by wet granulation. In this study, the effect of ethanol-water ratio and granulation time was examined.
Sustained release of Naproxen using Metolose SR
It is difficult to control the release if some active ingredients though dry blending with a polymer, followed by direct compression. Naproxen is an example drug that showed an initial release when tablets were made via this method.
HPMCP
Aqueous Dispersion Coating with Shin-Etsu Aqoat
Ammonia-Neutralized method part 1: Solution and film properties.
Enteric coating of hard gelatin capsules using HPMCP
The technical sheet gives an example of enteric coating of hard gelatin capsules using HPMCP.
Film solubility of HPMCP in various buffers
Film solubility (in terms of disintegration time of films specimens) of HPMCP was investigated.
HPMCP- Typical coating conditions for tablets
Examples of formulations using HPMCP in different solvent systems and their typical coating conditions for a batch size of 5kg.
HPMCP-Typical coating conditions for granules (1)
Examples of formulations using HPMCP in different solvent systems and their typical coating conditions for a batch size of 5kg.
HPMCP-Typical coating conditions for granules (2)
Examples of formulations using HPMCP in different solvent systems and their typical coating conditions for a batch size of 1.5kg.
Hydrolysis of HPMCP in ethanol-water solution
Stability of the ethanol-water coating solution of Hypromellose Phthalate (HP-55 & HP-50) was studied.
Molecular weight of HPMCP
Molecular weight of HPMCP is related to the viscosity of the polymer. This technical sheet includes the test method and results of Mw of all HPMCP grades.  
Residual solvent in ethanol/water HP-55 tablet coating
The ethanol/water system is commonly used for HPMCP tablet coating. Ethanol is categorized as a class 3 solvent in the ICH guidelines and its regulated upper limit is 5,000ppm. The effect of operating condition on the level of residual ethanol has been studied.
Shin-Etsu AQOAT®
Aqueous Dispersion Coating Using Shin-Etsu Aqoat
Coating parameters of a tablet batch size 5-100kg
Aqueous Dispersion Coating Using Shin-Etsu Aqoat
Preparation of coating dispersion
Aqueous Dispersion Coating Using Shin-Etsu Aqoat
Using a small tabletop coating machine we coated tablet batch size of 300g
Enteric Coating with Shin-Etsu Aqoat (HPMCAS) by Using Water-Ethanol Solution
HPMCAS can be used for solvent based coating. One of the advantages is using ethanol-water mixtures greater amount of water can be added to the formulation compared to an HPMCP.
Examples of Aqueous Dispersion Coating Using Shin-Etsu Aqoat
Coating parameters granules batch size 1.5kg
Minimum Film Formation Temperature of Shin-Etsu Aqoat
It is important to know minimum film Formation temperature of polymers for characterization of the coating formulations. We investigated minimum film Formation temperature of Shin-Etsu Aqoat (HPMCAS).
Molecular Weight of Shin-Etsu Aqoat (HPMCAS)
Please find the method and results of the molecular weight of Shin-Etsu Aqoat.

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