Healthcare

Capsules

Shin-Etsu excipients for capsules shell or filling.

Capsules

Capsules are flexible dosage filled with granules or pellets. Historically being based on gelatin, capsule manufacturers have meanwhile developed capsules with a hypromellose shell. The advantages are striking: better moisture stability of the capsule as hypromellose attracts less moisture than gelatin. Less risk as hypromellose is plant derived while gelatin is animal derived. The optimal solution for patients who follow a vegetarian or vegan diet. Our products PHARMACOAT® and TYLOPUR® are suitable for the preparation of capsules while our L-HPC product supports the dispersion and release of the capsule content once the capsule is opened in the GI tract.

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    Capsule shell

    Capsules prepared from hypromellose have advantages in comparison with gelatin based capsules. Hypromellose capsules show a better moisture stability and are suitable for vegetarian/vegan patients. Low viscosity hypromellose products like PHARMACOAT® and TYLOPUR® are suitable for capsule manufacturing.

    Recommended products

    GradesDescriptionPharmacopoeiaOriginRecommendationKnowledge Base
    PHARMACOAT® 645 Hypromellose 2910, 4.5 mPasUSP, EP, JPJapan Very suitable Select
    Related documentsLanguagesAvailable as Download or Request
    Brochures
    Guide to Applications
    Pharmaceutical Excipients
    PHARMACOAT®
    Safety Data Sheets
    Safety Data Sheet
    Technical Information
    An organic coating method with Pharmacoat, with mixed solvent of high content of ethanol and water
    Application of Pharmacoat as a carrier in solid dispersion
    Colour coating with Pharmacoat
    Effect of moisture content on the mechanical properties of cast HPMC films
    Effect of plasticizers and other additives on the mechanical properties of cast hypromellose films
    Filtration of Pharmacoat solutions
    Growth of microorganisms in aqueous solution of Pharmacoat
    Stability of Pharmacoat solution in sterilization
    Timed-release coating with Pharmacoat and Shin-Etsu AQOAT® for taste-masking effect
    PHARMACOAT® 606 Hypromellose 2910, 6 mPasUSP, EP, JPJapan Very suitable Select
    Related documentsLanguagesAvailable as Download or Request
    Brochures
    Guide to Applications
    Pharmaceutical Excipients
    PHARMACOAT®
    Safety Data Sheets
    Safety Data Sheet
    Technical Information
    An organic coating method with Pharmacoat, with mixed solvent of high content of ethanol and water
    Application of Pharmacoat as a carrier in solid dispersion
    Colour coating with Pharmacoat
    Effect of moisture content on the mechanical properties of cast HPMC films
    Effect of plasticizers and other additives on the mechanical properties of cast hypromellose films
    Filtration of Pharmacoat solutions
    Growth of microorganisms in aqueous solution of Pharmacoat
    Solubility of Pharmacoat 606 in alcohol-water mixtures
    Stability of Pharmacoat solution in sterilization
    Timed-release coating with Pharmacoat and Shin-Etsu AQOAT® for taste-masking effect
    PHARMACOAT® 615 Hypromellose 2910, 15 mPasUSP, EP, JPJapan Suitable Select
    Related documentsLanguagesAvailable as Download or Request
    Brochures
    Guide to Applications
    Pharmaceutical Excipients
    PHARMACOAT®
    Safety Data Sheets
    Safety Data Sheet
    Technical Information
    An organic coating method with Pharmacoat, with mixed solvent of high content of ethanol and water
    Application of Pharmacoat as a carrier in solid dispersion
    Colour coating with Pharmacoat
    Effect of moisture content on the mechanical properties of cast HPMC films
    Effect of plasticizers and other additives on the mechanical properties of cast hypromellose films
    Filtration of Pharmacoat solutions
    Growth of microorganisms in aqueous solution of Pharmacoat
    Stability of Pharmacoat solution in sterilization
    Timed-release coating with Pharmacoat and Shin-Etsu AQOAT® for taste-masking effect
    L-HPC LH-11 50 µm, 11 % HPONF, EP, JPJapan Suitable Select
    Related documentsLanguagesAvailable as Download or Request
    Brochures
    Guide to Applications
    L-HPC
    Pharmaceutical Excipients
    Safety Data Sheets
    Safety Data Sheet
    TYLOPUR® 645 Hypromellose 2910, 4.5 mPasUSP, EP, JPGermany Very suitable Select
    Related documentsLanguagesAvailable as Download or Request
    Brochures
    Guide to Applications
    Pharmaceutical Excipients
    Tylopur®
    Safety Data Sheets
    Tylopur 645
    TYLOPUR® 605 Hypromellose 2910, 5 mPasUSP, EP, JPGermany Very suitable Select
    Related documentsLanguagesAvailable as Download or Request
    Brochures
    Guide to Applications
    Pharmaceutical Excipients
    Tylopur®
    Safety Data Sheets
    Tylopur 605
    TYLOPUR® 606 Hypromellose 2910, 6 mPasUSP, EP, JPGermany Very suitable Select
    Related documentsLanguagesAvailable as Download or Request
    Brochures
    Guide to Applications
    Pharmaceutical Excipients
    Tylopur®
    Safety Data Sheets
    Tylopur 606
    TYLOPUR® 615 Hypromellose 2910, 15 mPasUSP, EP, JPGermany Suitable Select
    Related documentsLanguagesAvailable as Download or Request
    Brochures
    Guide to Applications
    Pharmaceutical Excipients
    Tylopur®
    Safety Data Sheets
    Tylopur 615
    METOLOSE® 65SH-5 Hypromellose 2906, 5 mPasUSP, EP, JPJapan Very suitable Select
    Related documentsLanguagesAvailable as Download or Request
    TYLOPUR® 65SH-5 Hypromellose 2906, 5 mPasUSP, EP, JPGermany Very suitable Select
    Related documentsLanguagesAvailable as Download or Request
    Safety Data Sheets
    Tylopur 65SH-5

    Dispersing aid for capsule filling

    The release of a drug is filled in hard capsules tends to be delayed because the materials in the capsules are clogged; this delay is especially significant for herbal medications. However, if L-HPC is used together with a drug as a filler, clogging can be prevented because L-HPC absorbs water and disintegrates in a shorter time, which results in the rapid release of the drug.

    Recommended products

    GradesDescriptionPharmacopoeiaOriginRecommendationKnowledge Base
    L-HPC LH-11 50 µm, 11 % HPONF, EP, JPJapan Suitable Select
    Related documentsLanguagesAvailable as Download or Request
    Brochures
    Guide to Applications
    L-HPC
    Pharmaceutical Excipients
    Safety Data Sheets
    Safety Data Sheet
    L-HPC LH-B1 50 µm, 11 % HPONF, EP, JPJapan Very suitable Select
    Related documentsLanguagesAvailable as Download or Request
    Brochures
    Guide to Applications
    L-HPC
    Pharmaceutical Excipients
    Safety Data Sheets
    Safety Data Sheet
    L-HPC NBD-020 45 µm, 14 % HPONF, EP, JPJapan Suitable Select
    Related documentsLanguagesAvailable as Download or Request
    Brochures
    Guide to Applications
    L-HPC
    Pharmaceutical Excipients
    Safety Data Sheets
    Safety Data Sheet

    Shin-Etsu’s commitment

    • High quality and high batch to batch consistency of our excipients
    • Long established manufacturer of pharmaceutical excipients
    • Production in Japan and Germany

    Get in contact

    For further technical information or advice please contact your local technical sales contact.

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    Amorphous Solid Dispersion

    Solubility enhancement of poorly soluble APIs.

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