Healthcare
Liquid and semi-solid dosage forms utilize mostly hypromellose like PHARMACOAT® and TYLOPUR®, as well as methyl cellulose METOLOSE®. These excipients are used to increase viscosity, or to utilize the non-ionic surfactant properties of the cellulose ethers.
METOLOSE® have been known for a long time and have found wide acceptance for liquid preparation as a thickener in aqueous systems.
Shin-Etsu METOLOSE® and TYLOPUR® are low fiber content cellulose ethers for eye drop application. These products are excipients and do not qualify as API.
METOLOSE® SM grades are available which will disperse in water to produce viscous colloidal solutions suitable for use as suspending agents. Methyl cellulose is non-ionic and therefore stable over pH range of 3-11, and are compatible with many ionic additives.
PHARMACOAT® and TYLOPUR® are suitable for dry syrup preparation.
METOLOSE® and TYLOPUR® can be used for semi solid drug products.
Transparent films are obtained by casting METOLOSE®, PHARMACOAT® and TYLOPUR® solutions. Although METOLOSE® films are relatively rigid they can be made flexible by adding plasticizers such as glycerin, propylene glycol, sorbitol, and triethyl citrate. The film properties markedly depend on the moisture content.
For further technical information or advice please contact your local technical sales contact.
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